固相萃取-液质联用分析药物和个人护理品

建立了固相萃取-液质联用分析药物和个人护理品(PPCPs)的方法,采用Oasis HLB固相萃取柱分别在酸性条件下和碱性条件下对PPCPs进行富集提取,该法对于宜兴地区能够检出的30种PPCPs均具有良好的线性,相关系数为0.990~0.999,检出限为1.37~10.12 ng/L。应用该法对宜兴地区地表水中存在的PPCPs进行分析,结果显示30种PPCPs均有不同程度检出,分布最广泛的7种分别为避蚊胺、阿替洛尔、对乙酰氨基酚、普鲁卡因、β-雌二醇、卡马西平和苯佐卡因,阿替洛尔浓度较高,普遍为5~600 ng/L。避蚊胺虽然出现频率最高,但其在各个采样点浓度偏低,普遍为1~50 ng/L。

Determination of Pharmaceutical and Personal Care Products by Solid Phase Extraction Coupled with LC/MS

A method for determination of pharmaceutical and personal care products ( PPCPs) was developed using solid phase ex-traction-liquid chromatography/mass spectrometry ( SPE-LC/MS) .The PPCPs were concentrated by Oasis HLB solid phase extrac-tion column at acidic and alkaline conditions .Thirty PPCPs were detected in Yixing City by the developed method with the correla-tion coefficient in the range of 0.990~0.999 and the detection limit in the range of 1.37~10.12 ng/L.The most frequently detec-ted PPCPs were diethyltoluamede , atenolol, paracetamol, procaine, beta-estradiol, carbamazepine and benzocaine .Atenolol had the highest concentration of these PPCPs with the range of 500~600 ng/L.Diethyltoluamede was the most frequently discovered PPCPs , however , the concentrations were low with the range of 1~50 ng/L.