呼吸性煤尘与尘肺的剂量-反应关系分析

分析6个煤矿3082名煤尘接尘工人,其中包括51名尘肺患者接尘资料,首先通过比例换算法,按总煤尘EIC/TWA为1.5、总煤尘TWA/呼吸性煤尘TWA为3.82,将总煤尘EIC转换为呼吸性煤尘TWA;再用寿命表法分析累计接尘量与尘肺发病的剂量-反应关系,得到回归方程logit=5.714lgd-18.902(r=0.939),采用区间估计法,得接尘30年尘肺累计发病率为1%时,呼吸性煤尘TWA为6.52mg/m3,对估算结果取1.2的安全系数,呼吸性煤尘接触浓度管理限值为5mg/m3。

Study on the dose-response relationship between respirable coal dust and pneumoconiosis

This paper analyzed the data of 3082 workers exposed to coal dust and 51 pneumoconiosis in six mines.Firstly,according to the Environmental Instantaneous Concentration /the Time Weighted Average of total coal dust being 1.5 and the Time Weighted Average of total coal dust/the Time Weighted Average of respirable coal dust being 3.82,the Environmental Instantaneous Concentration of total coal dust was converted into the Time Weighted Average of respirable coal dust,secondly,life-table was applied to analyze the dose-response relationship between the cumulative dust exposed and the incidence of pneumoconiosis,get regression equation logit=5.714lg d-18.902(r=0.939),according to the interval estimate,when workers exposed to coal dust 30 years,the cumulative incidence of pneumoconiosis being 1%,the Time Weighted Average of respirable coal dust is 6.52 mg/m3.Devide the outcome by safety coefficient of 1.2,the Authorized Limit-Personal Exposure Concentration of respirable coal dust is 5mg/m3.