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Phthalides as promising insecticides against Tuta absoluta (Lepidoptera: Gelechiidae)
Authors:Elizeu S Farias  Eliete M P Silva  Milena G Teixeira  Jhulyana S Ferreira  Elson S Alvarenga  Marcelo C Picanço
Institution:1. Departamento de Entomologia, Universidade Federal de Vi?osa, Vi?osa, Minas Gerais, Brazilelizeu.farias@ufv.br elizeusf21@gmail.com;3. Departamento de Entomologia, Universidade Federal de Vi?osa, Vi?osa, Minas Gerais, Brazil;4. Departamento de Química, Universidade Federal de Vi?osa, Vi?osa, Minas Gerais, Brazil
Abstract:In this study, the insecticide potential of eight phthalides derived from furan-2(5H)-one was evaluated against Tuta absoluta (Meyrick) (Lepidoptera: Gelechiidae) larvae. The potency of the most active phthalides and the susceptibility of six different T. absoluta populations to these compounds were determined. The toxicity of these molecules to two non-target species (Solenopsis saevissima Smith and Tetragonisca angustula Latreille) was also evaluated. Two phthalides (3 and 4) presented insecticide potential against T. absoluta. Phthalide 4 was as toxic as piperine (positive control) and both phthalides exhibited rapid action (LT50 < 2 hours). The variation in the susceptibility of T. absoluta populations to the phthalides 3 and 4 was low. Neither phthalide presented physiological selectivity for non-target species.

Therefore, the phthalides 3 and 4 are promising molecules, or at least, a starting point for a chemical optimization program leading to formulations for the management of the tomato leafminer. The application of such products should be conducted according to the principles of ecological selectivity.

Keywords:Tomato leafminer  isobenzofuranones  invasive pest  susceptibility index  Solenopsis saevissima  Tetragonisca angustula
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