Diazinon treatment effects on heart and skeletal muscle enzyme activities |
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| Authors: | J G Wilkinson W Rajendra P C Oloffs E W Banister |
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| Institution: | 1. School of Physical Education , University of Wyoming , Laramie, Wy, 82071;2. School of Kinesiology and Department of Biological Sciences , Simon Fraser University , Burnaby, B.C., V5A 1S6 |
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| Abstract: | Abstract The effects of low levels of diazinon treatment on four marker enzymes in rat heart and skeletal muscle have been investigated. Adult male Wistar rats were treated twice a week with a dose of 0.5 ml‐kg‐1day‐1 diazinon for 28 weeks. Diazinon treated rats gained significantly less weight than Sham‐treated controls. Typical differences in Succinate dehydrogenase (SDH), Lactate dehydrogenase (LDH), Phosphofructo kinase (PFK) and Hexokinase (HK) activities were observed between heart and skeletal muscles. Diazinon feeding had no effect on heart, soleus, gastrocnemius and plantaris SDH, LDH and PFK enzyme activities after 28 weeks. HK activity was significantly increased in sham‐control soieus and plantaris muscles after 28 weeks. Diazinon feeding inhibited HK activity in plantaris muscle after 28 weeks treatment These results demonstrate that chronic low levels of diazinon have little effect on the glycolytic and oxidative activity in heart and skeletal muscle. |
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| Keywords: | Diazinon SDH LDH PFK HK Heart Skeletal Muscle |
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