Induction of hepatic drug metabolizing enzymes in mammals by pesticides: A review |
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| Authors: | Ernest Hodgson Arun P Kulkarni David L Fabacher Karen M Robacker |
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| Institution: | Toxicology Program, Department of Entomology , North Carolina State University , Raleigh, North Carolina, 27650 |
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| Abstract: | Abstract The induction of drug metabolizing enzymes in mammals is summarized including both enzymes of the cytochrome P‐450‐dependent microsomal mixed function oxidase system and glutathione S‐transferases. Particular emphasis is placed on the role of pesticides as inducers, the early work being summarized while investigations carried out at North Carolina State University are considered in greater detail. Finally, the possible significance of induction is considered. |
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| Keywords: | Enzyme induction drug metabolizing enzymes cytochrome P‐450 pesticides |
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