Biochemical effects of some organo‐phosphorus insecticides on new targets in white rats |
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Authors: | AH El‐Sebae EE Enan SA Soliman S El‐Fiki E Khamees |
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Institution: | Univ. of Alex. Research Center and High Institute of Public Health , Alexandria, Egypt |
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Abstract: | Abstract The three S‐n‐propyl phosphates and phosphothioates: RH 218, profenofos and prothiophos were compared with fenitrothion in their potential as inhibitors of rat liver and brain AChE. Fenitrothion was more potent as an inhibitor than the three S‐n‐propyl derivatives. Incubation of hepatic protein enhanced ChE inhibition in brain in the case of fenitrothion, while it reduced the inhibitory effect of the S‐n‐propyl derivatives. On the other hand, the four organophosphorus esters caused hypoglycemia in both male and female rats and also reduced their blood urea with different degrees. |
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Keywords: | Hepatic protein hypoglycemia blood sugar blood urea cholinesterase rat brain profenofos prothiophos and fenitrothion |
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