Rat urinary metabolites from O,O‐diethyl‐O‐(3, 5, 6‐trichloro‐2‐pyridyl) phosphorothioate |
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Authors: | J E Bakke V J Fell C E Price |
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Institution: | Agricultural Research Service, United States Department of Agriculture , Metabolism and Radiation Research Laboratory , Fargo, North Dakota, 58102 |
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Abstract: | Abstract Rats metabolized single oral doses of O,O‐diethy1–0‐(3,5,6‐trichloro‐2‐pyridyl‐2,6‐14C) phosphorothioate to at least six radiolabeled urinary metabolites. The urine contained about 90 percent of the dose. Three of these metabolites were identified as the glucuronide of 3,5,6‐trichloro‐2‐pyridinol (80% the urinary l4C), a glycoside of 3,5,6‐trichloro‐2‐pyridinol (4%), and 3,5,6‐trichloro‐2‐pyridinol (12%). |
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Keywords: | chlorpyrifos glucuronide glycoside diethyl phosphorothioate metabolism |
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