Antiestrogenic activity of anthropogenic and natural chemicals |
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Authors: | José María Navas Helmut Segner |
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Institution: | (1) Department of Chemical Ecotoxicology, UFZ Centre for Environmental Research, Permoserstr. 15, D-04318 Leipzig, Germany |
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Abstract: | A number of natural and man-made chemicals possess antiestrogenic activity, i.e. they antagonize a broad spectrum of estrogen-induced
responses in vertebrates. Examples of antiestrogens include dioxin, furan and PCB congeners, certain PAHs, pesticides and
indol-3-carbinol derivatives. Major mechanisms of antiestrogenicity are antagonistic action of chemicals at the estrogen receptor,
or binding of chemicals to the arylhydrocarbon (Ah) receptor and subsequent interaction with estrogen-responsive genes. Toxicological
consequences resulting from antiestrogenic activity have not been conclusively demonstrated to date, although antiestrogenic
compounds could critically affect sensitive reproductive and developmental processes. |
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Keywords: | Antiestrogenicity toxicological consequences endocrine disrupters estrogen receptors endocrine disrupters Ah receptor endocrine disrupters |
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