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Bioconcentration potential (BCP) of 2,3,7,8-Tetrachlorodibenzop-dioxin (2,3,7,8-TCDD) in terrestrial organisms including humans |
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| Authors: | Harald J Geyer Irene Scheunert Johannes G Filser Friedhelm Korte |
| Institution: | 1 Gesellschaft für Strahlen- und Umweltforschung Institut für Ökologische Chemie D - 8042, Neuherberg, F.R.G. 2 Gesellschaft für Strahlen- und Umweltforschung Institut für Toxikologie D - 8042, Neuherberg, F.R.G. |
| Abstract: | The bioconcentration factors (BCFs) of 2,3,7,8-TCDD in adipose tissue of rats, beef cattle and monkeys have been calculated. The bioconcentration potential of TCDD in man was calculated by two indirect methods: 1) from daily intake of TCDD and its measured concentrations in adipose tissues and 2) from measured half-life and measured concentrations in body fat at steady state using a linear one compartment pharmacokinetic model. The BCFs in humans calculated by both methods are between 104 and 206, or 153, respectively. |
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