Structure of the major metabolite of 5-ethyl-2′-deoxyuridine in rats |
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| Authors: | R Kaul K Keppeler G Kiefer B Hempel P Fischer |
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| Institution: | Research Laboratories, Robugen GmbH, Alleenstrasse 22, D-7300 Esslingen 1 Germany;Institut für Organische Chemie der Universität Pfaffenwaldring 55, D-7000 Stuttgart 80 Germany |
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| Abstract: | The major metabolite of 5-ethyl-2′-deoxyuridine in rats has been isolated and purified by preparative thick layer and column chromatography. By mass and 1H NMR spectroscopy, it was identified as 5-(1-hydroxyethyl) uracil; the structure was confirmed by comparison with an authentic sample. |
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