| 二氧化硫对小鼠肺细胞DNA损伤的研究 |
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| 引用本文： | 孟紫强,秦国华,张波,阮爱东,张建彪.二氧化硫对小鼠肺细胞DNA损伤的研究[J].环境科学学报,2002,22(3):389-392. |
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| 作者姓名： | 孟紫强 秦国华 张波 阮爱东 张建彪 |
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| 作者单位： | 山西大学环境医学与毒理学研究所,山西大学生命科学系,太原,030006 |
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| 基金项目： | 国家自然科学基金 (No .30 0 70 6 4 7)，山西省自然科学基金资助项目 |
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| 摘 要： | 运用单细胞凝胶电泳技术（又称彗星试验）研究了SO2吸入对小鼠肺细胞DNA的损伤。结果发现，SO2可引起小鼠肺细胞DNA损伤，随SO2吸入浓度的增高而DNA损伤加重，具有明确的剂量效应关系。结果指出，即使在低浓度SO2吸入（7mg/m^3）的条件下，有DNA损伤的肺细胞也达96．8％，表明肺细胞对SO2的毒作用非常敏感。结果还指出，SO2对雌性小鼠肺细胞的DNA损伤比雄性小鼠弱，其原因尚待研究。
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| 关 键 词： | 肺细胞 二氧化硫 DNA损伤 小鼠 彗星试验 大气污染 |
| 文章编号： | 0253-2468(2002)-03-0389-04 |
| 收稿时间： | 7/5/2001 12:00:00 AM |
| 修稿时间： | 2001年7月5日 |
Damage effects of sulfur dioxide inhalation on DNA of lung cells from mice |
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| MENG Ziqiang,QIN Guohu,ZHANG Bo,RUAN Aidong and ZHANG Jianbiao.Damage effects of sulfur dioxide inhalation on DNA of lung cells from mice[J].Acta Scientiae Circumstantiae,2002,22(3):389-392. |
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| Authors: | MENG Ziqiang QIN Guohu ZHANG Bo RUAN Aidong and ZHANG Jianbiao |
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| Institution: | Institute of Environmental Medicine and Toxicology, Department of Life Sciences, Shanxi University, Taiyuan 030006,Institute of Environmental Medicine and Toxicology, Department of Life Sciences, Shanxi University, Taiyuan 030006,Institute of Environmental Medicine and Toxicology, Department of Life Sciences, Shanxi University, Taiyuan 030006,Institute of Environmental Medicine and Toxicology, Department of Life Sciences, Shanxi University, Taiyuan 030006 and Institute of Environmental Medicine and Toxicology, Department of Life Sciences, Shanxi University, Taiyuan 030006 |
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| Abstract: | The damage effects of sulfur dioxide (SO 2) inhalation on DNA of lung cells from mice were studied with the single cell microgel electrophoresis tecknique (Comet test). The results show that DNA damage of lung cells is in a dose dependent manner. The results indicated that DNA of lung cells is very sensitive to SO\-2, even under low concentrations as 7?mg(SO 2)/m 3, the lung cells with DNA damaged also reached to 96 8%. it implies the lung cells of mammalian animals are very sensitive to SO 2 inhalation. The results also indicate that DNA damage of the lung cells from male mice is more serious than that from female mice, that that remains to be further studied. These results lead us to conclusion: SO 2 pollution even at low concentrations also has a potential risk to damage genetic material DNA of lung cells from mammalian animals. |
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| Keywords: | sulfur dioxide DNA damage lung mice comet test |
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