| 布洛芬对黄颡鱼I相代谢酶及其抗氧化系统的影响 |
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| 引用本文： | 武小燕,彭颖,廖伟,李义刚,苏甜,欧瑞康,陈昆慈,李凯彬,聂湘平.布洛芬对黄颡鱼I相代谢酶及其抗氧化系统的影响[J].环境科学学报,2013,33(4):1208-1214. |
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| 作者姓名： | 武小燕 彭颖 廖伟 李义刚 苏甜 欧瑞康 陈昆慈 李凯彬 聂湘平 |
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| 作者单位： | 1. 暨南大学生命科学技术学院生态系/水生生物研究所,广州,510632
2. 中国水产科学研究院珠江水产研究所,广州,510380 |
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| 基金项目： | 国家科技支撑计划课题(No.2012BAC07B05) |
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| 摘 要： | 使用环境相关浓度水平(0.05、0.5、5、50 μg· L-1)的布洛芬(Ibuprofen,IBU)对黄颡鱼进行水体暴露,研究IBU对黄颡鱼Ⅰ相代谢酶及其抗氧化系统的影响.结果表明,随着暴露时间的延长,IBU对黄颡鱼肝脏Ⅰ相代谢P450酶系的氨基比林-N-脱甲基酶(APND)、红霉素-N-脱甲基酶(ERND)、7-乙氧基-异吩噁唑酮-脱乙基酶(EROD)和Ⅱ相代谢谷胱甘肽硫转移酶(GST)均表现出先诱导后抑制的作用.暴露24 h时,IBU浓度为5 μg· L-1实验组对Ⅰ相代谢酶APND和ERND的诱导程度最大.当暴露时间达到168 h时,0.5 μg·L-1浓度组中APND和ERND活性均受到极显著抑制.Ⅰ相代谢酶EROD活性在暴露24 h后,除0.05 μg· L-1浓度组无明显变化外,其它浓度组皆受到显著诱导,随着暴露时间延长到168 h时,逐渐恢复到初始水平.GST活性在暴露24 h后,除0.05 μg·L-1浓度组外,其它浓度组均受到最大程度的诱导,过氧化氢酶(CAT)在暴露168 h时被显著诱导.各浓度组丙二醛(MDA)含量在暴露24 h时较对照组显著下降,72 h时其含量达到最高值.其中,ERND响应较为敏感,适合作为布洛芬暴露的生物标记物.
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| 关 键 词： | 布洛芬 黄颡鱼 肝脏酶活 生物标记物 |
| 收稿时间： | 6/6/2012 12:00:00 AM |
| 修稿时间： | 2012/8/31 0:00:00 |
Effects of Ibuprofen on the phase I metabolic enzymes and antioxidant defence system of the Yellow Catfish (Pelteobagrus fulvidraco) |
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| WU Xiaoyan,PENG Ying,LIAO Wei,LI Yigang,SU Tian,OU Ruikang,CHEN Kunci,LI Kaibin and NIE Xiangping.Effects of Ibuprofen on the phase I metabolic enzymes and antioxidant defence system of the Yellow Catfish (Pelteobagrus fulvidraco)[J].Acta Scientiae Circumstantiae,2013,33(4):1208-1214. |
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| Authors: | WU Xiaoyan PENG Ying LIAO Wei LI Yigang SU Tian OU Ruikang CHEN Kunci LI Kaibin and NIE Xiangping |
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| Institution: | Department of Ecology/Institute of the Hydrobiology, School of Life Science and Technology, Jinan University, Guangzhou 510632;Department of Ecology/Institute of the Hydrobiology, School of Life Science and Technology, Jinan University, Guangzhou 510632;Department of Ecology/Institute of the Hydrobiology, School of Life Science and Technology, Jinan University, Guangzhou 510632;Department of Ecology/Institute of the Hydrobiology, School of Life Science and Technology, Jinan University, Guangzhou 510632;Department of Ecology/Institute of the Hydrobiology, School of Life Science and Technology, Jinan University, Guangzhou 510632;Department of Ecology/Institute of the Hydrobiology, School of Life Science and Technology, Jinan University, Guangzhou 510632;Pearl River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou 510380;Pearl River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou 510380;Department of Ecology/Institute of the Hydrobiology, School of Life Science and Technology, Jinan University, Guangzhou 510632 |
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| Abstract: | |
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| Keywords: | Ibuprofen Pelteobagrus fulvidraco hepatic enzyme biomarkers |
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