过氧化钙去除水中糖皮质激素的响应面分析

结合响应面方法Box-Behnken实验设计，对过氧化钙降解代表性糖皮质激素曲安奈德过程中的影响因素（过氧化钙投加量、溶液初始pH值、反应时间、糖皮质激素初始浓度）进行了探讨与分析，并对反应条件进行了优化.得出最优反应条件为：过氧化钙投加量4g/L；溶液初始pH值5.7，反应时间15.7min，初始TA浓度为0.06mmol/L.最优条件下模型预测的目标物降解率（88.6%）和实验得出的降解率（82.8%）数值接近，说明此响应面模型能够较准确预测过氧化钙对糖皮质激素的去除效果，并用电子顺磁共振仪对过氧化钙降解有机物过程中的作用自由基进行了检测.研究结果对过氧化钙技术去除有机污染物的发展有一定的参考价值.

Response surface analysis of glucocorticoid removal by calcium peroxide

Performance of calcium peroxide (CaO₂) in removing glucocorticoid (GC) contamination was investigated with triamcinolone acetonide (TA) as the representative target compound. An experimental design based on the response surface methodology (RSM) was applied to assess the individual and interaction effects of several operating parameters (CaO₂ dosage, initial pH value, reaction time, and TA concentration) on TAremoval. Based on the results of RSM, the optimal conditions were obtained as follows:CaO₂ dosage at 4g/L, initial pH=5.7, reaction time=15.7 min, and initial TA concentration=0.06 mmol/L. Moreover, additional experimental result obtained under optimal conditions (82.8%) was found to be very close to the predicted value (88.6%). These results indicated that the response model could be an effective method to describe the removal of GC by CaO₂. Finally, the role of reactive oxygen species (ROS) in GC degradation was tested by electron paramagnetic resonance spectroscopy (EPR). This study contributes significantly to the improvement and better understanding of CaO₂ oxidation and GC treatment processes.