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四种拟除虫菊酯类农药的环境雌激素活性研究
引用本文:邴欣,汝少国.四种拟除虫菊酯类农药的环境雌激素活性研究[J].中国环境科学,2009,29(2):152-156.
作者姓名:邴欣  汝少国
作者单位:中国海洋大学海洋生命学院,山东,青岛,266003
基金项目:国家自然科学基金,山东省自然科学基金 
摘    要:将金鱼(Carassius auratus)分别暴露于0.1mg/L甲氰菊酯、氰戊菊酯、溴氰菊酯和0.5mg/L氯氰菊酯21d后,尾静脉取血,离心分离获得血浆,利用Western-blot方法检测金鱼血浆中是否有卵黄原蛋白产生,同时测定金鱼生殖腺指数、γ-谷氨酰转移酶和乳酸脱氢酶活性.结果表明,对照组雄性金鱼血浆中未检测到卵黄原蛋白,4种拟除虫菊酯农药均能诱导雄性金鱼分泌卵黄原蛋白,而且溴氰菊酯和氯氰菊酯明显降低了雄鱼生殖腺指数,4种农药均能够明显抑制精巢γ-谷氨酰转移酶和乳酸脱氢酶活性.由此可见,4种拟除虫菊酯类农药具有潜在的环境雌激素活性和生殖毒性.

关 键 词:环境雌激素  拟除虫菊酯农药  卵黄原蛋白  生殖腺指数  γ-谷氨酰转移酶  乳酸脱氢酶  
收稿时间:2008-07-23;

Determination of environmental estrogenic activity of four pyrethroid pesticides
BING Xin,RU Shao-guo.Determination of environmental estrogenic activity of four pyrethroid pesticides[J].China Environmental Science,2009,29(2):152-156.
Authors:BING Xin  RU Shao-guo
Abstract:The induction of vitellogenin (VTG) of male goldfish (Carassius auratus) by four pyrethroid pesticides was investigated, attempting to determine whether these pesticides have environmental estrogenic activity. Goldfish were exposed to fenpropathrin, fenvalerate, deltamethrin (0.1 mg/L) and cypermethrin (0.5 mg/L) for 21d, respectively. The blood of each goldfish collected from caudal vessel and the VTG production in male fish was detected through Western-blotting analysis. The gonadosomatic index and the activity of γ-glutamyl transpeptidase (γ-GTP) and lactic dehydrogenase (LDH) were assayed. All the four pesticides significantly induced the synthesis of VTG in male goldfish. Deltamethrin and cypermethrin decreased gonadosomatic index, fenpropathrin, fenvalerate, deltamethrin and cypermethrin inhibited the activity of γ-GTP and LDH markedly, suggesting that fenpropathrin, fenvalerate, deltamethrin and cypermethrin have the potential of environmental estrogenic activity and reproductive toxicity.
Keywords:environmental estrogen  pyrethroid pesticide  vitellogenin  gonadosomatic index  γ-GTP  LDH
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