四溴双酚A和镉复合污染对不同生物体的安全阈值

以赤子爱胜蚓（Eisenia fetida）、斑马鱼（Zebrafish）作为受试生物，进行急性毒性试验，死亡率、超氧化物歧化酶（SOD）、过氧化氢酶（CAT）为效应指标，采用基准剂量（BMD）法推导四溴双酚A （TBBPA）和镉（Cd）单一及联合暴露对不同生物体的安全阈值.结果表明，在本研究的试验剂量范围内，蚯蚓、斑马鱼TBBPA、Cd暴露剂量与死亡率、SOD、CAT活性效应指标存在明显剂量-效应关系.单一暴露下，CAT、SOD活性指标最敏感，蚯蚓和斑马鱼的TBBPA安全阈值分别为0.95，0.44mg/L，Cd安全阈值分别为71.17，0.42mg/L.联合暴露下安全阈值小于单一暴露.蚯蚓、斑马鱼TBBPA安全阈值分别为0.33，0.024mg/L，Cd为6.45，0.176mg/L.

The safety threshold of joint exposure of tetrabromobisphenol A and cadmium on different organisms

Acute toxicity test of Eisenia foetida and Zebrafish was carried out, the toxicity data of mortality, superoxide dismutase (SOD) and catalase (CAT) were obtained. The BMD method was used to derive the safety threshold of tetrabromobisphenol A (TBBPA) and cadmium (Cd) for different organisms under single and combined exposure conditions. The results showed that there were significant dose-effect relationships between the exposure doses of TBBPA, Cd and the mortality, SOD and CAT indicators in the experimental dose range of this study. CAT and SOD indicators were most sensitive to single exposure, and the safety thresholds of TBBPA for Eisenia fetida and Zebrafish were 0.95, 0.44mg/L, Cd were 71.17, 0.42mg/L, respectively. The safety threshold of combined exposure was less than single exposure. The safety threshold of TBBPA for Eisenia fetida and Zebrafish were 0.33, 0.024mg/L, and Cd were 6.45, 0.176mg/L, respectively.