咪唑类离子液体系列对卤虫的急性毒性研究

选取卤虫作为实验生物,研究了1-丁基,1-辛基,1-十二烷基-3甲基咪唑盐酸盐( Cnmim]Cl](n = 4,8,12) ) 3种离子液体的暴露对卤虫个体存活率的影响.同时,选取了实验室常用的有机试剂甲醇和乙腈,无机化学品重铬酸钾作为阳性对照.根据剂量效应曲线的拟合结果发现,受试离子液体系列随着咪唑环上烃基侧链碳原子数的增加,对卤虫的毒性效应也相应增强,3种离子液体对卤虫的LC50-24h依次为171.1,133.6,17.76μg/mL.离子液体对卤虫的LC50-24h比甲醇(LC50-24h=84.83mg/mL)和乙腈(LC50-24h=52.84mg/mL)低了2~3个数量级,重铬酸钾对卤虫的(LC50-24h=16.87μg/mL)与离子液体对卤虫的LC50-24h处于同一水平.

Research on the acute toxicity of imidazolium ionic liquids on the brine shrimp

In this paper, the effects of three imidazolium ionic liquids, 1-butyl-, 1-octyl- and 1-dodecyl-3- methylimidazolium chloride on the inhibiting concentration to the growth of brine shrimp in artificial sea water were carefully studied. At the same time, toxic organics such as methanol and acetonitrile and toxic inorganics like potassium dichromate were selected as positive control for the investigation of the effect of ILs on the brine shrimp. Dose-response curve fittings were established for the ionic liquids and the positive control toxins. The experimental results showed that with increasing the alkyl chain length of the ionic liquids, their toxicity to brine shrimp accordingly increased (LC50-24h values were 171.1, 133.6, 17.76μg/mL for the three ionic liquids, respectively). The LC50-24h values of the three imidazolium ionic liquids were found to be 10-2 to 10-3 of the values of methanol and acetonitrile while being much close to that of potassium dichromate.