| 氯化甲基汞对大鼠海马c-jun蛋白表达的影响 |
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| 引用本文： | 程金平,王文华,贾金平.氯化甲基汞对大鼠海马c-jun蛋白表达的影响[J].中国环境科学,2003,23(4):0-0. |
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| 作者姓名： | 程金平 王文华 贾金平 |
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| 作者单位： | 上海交通大学环境科学与工程学院 上海200240 |
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| 基金项目： | 国家自然科学基金资助项目(20177013)，上海交通大学985工程资助项目(113516001) |
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| 摘 要： | 为了探讨氯化甲基汞(MMC)对大鼠海马损伤的分子机制,应用免疫组织化学方法观察了氯化甲基汞对大鼠海马JUN蛋白表达的影响(对照组为0.9%生理盐水、暴露组浓度分别为0.05,0.5,5mg/kg;取样时间分别为20,60,240,1440min).结果发现,暴露组大鼠海马JUN蛋白表达均高于对照组,氯化甲基汞对大鼠海马JUN蛋白表达与其浓度之间有一定的剂量反应关系,表明即刻早期基因(c-jun)参与了氯化甲基汞对海马损害的毒性过程.
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| 关 键 词： | 氯化甲基汞 海马 c-jun 基因表达 |
| 文章编号： | 1000-6923(2003)04-0431-04 |
| 收稿时间： | 1900-01-01; |
| 修稿时间： | 2002年11月25 |
Effect of methylmercuric chloride on the expression of c-jun protein in rat hippocampus |
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| CHENG Jin-ping,WANG Wen-hua,JIA Jin-ping.Effect of methylmercuric chloride on the expression of c-jun protein in rat hippocampus[J].China Environmental Science,2003,23(4):0-0. |
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| Authors: | CHENG Jin-ping WANG Wen-hua JIA Jin-ping |
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| Abstract: | In order to probe into the molecular mechanism of injury in rat hippocampus by methylmercuric chloride (MMC), the effect of MMC on the expression of JUN protein in rat hippocampus was observed using immunocyto-chemical method (the control group was physiological saline of 0.9%, the concentrations of expose groups were 0.05, 0.5, 5mg/kg respectively, the sampling times were 20, 60, 240, 1440min). The expression of JUN protein in rat hippocampus of the expose groups was higher than that of the control group; there was a definite dose-response relationship between concentration of methylmercury chloride and its expression of JUN protein, indicating that IEG (c-jun) participated in the toxicity process of hippocampus injury by methylmercuric chlorid. |
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| Keywords: | methylmercuric chloride hippocampus c-jun gene expression |
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