BDE-47在紫贻贝中的分布、蓄积、消除和毒性效应

以紫贻贝(Mytilus galloprovincialis)为试验生物,研究了2,2',4,4'-四溴联苯醚(BDE-47)在贻贝组织中的分布、生物蓄积和消除动态,并探究BDE-47对贻贝的毒性作用.结果发现:紫贻贝对BDE-47有较强的生物蓄积能力和一定的消除能力,且蓄积具有组织特异性和浓度依赖性,消化腺和鳃是BDE-47蓄积的靶器官.蓄积和消除阶段各组织中BDE-47含量符合一阶非线性累积/衰减模型.0.01~1μg/L暴露浓度下,BDE-47在贻贝各组织中的半衰期为0.68~7.62d,生物富集系数(BCFs)为3217~140970L/Kg.BDE-47暴露引发消化腺和鳃抗氧化防御系统及组织损伤,其中超氧化物歧化酶(SOD)活性、丙二醛(MDA)含量和谷胱甘肽-S-转移酶(GST)活性可作为BDE-47暴露的候选生物标志物.

Tissue distribution,accumulation, elimination characteristics and toxicity of 2,2’,4,4’-tetrabromodiphenyl ether in blue mussel

The distribution, bioaccumulation and elimination dynamics of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) in mussel (Mytilus galloprovincialis) tissues were studied, and the toxic effects of BDE-47 on mussel were investigated. Results showed that blue mussel had strong bioaccumulation ability and certain elimination ability to BDE-47, and the accumulation was tissue-specific and concentration-dependent. Digestive gland and gill were the target organs where BDE-47 accumulated. The content of BDE-47 in tissues at accumulation or elimination stage accorded with the first-order nonlinear accumulation/attenuation model. The elimination half-life and bioconcentration factors (BCFs) of BDE-47 in mussel tissues were 0.68~7.62d and 3217~140970L/Kg under 0.01~1μg/L exposure solution, respectively. BDE-47exposure induced antioxidant defence system and tissue damages in both digestive gland and gill. Superoxide dismutase (SOD) activity, malondialdehyde (MDA) content and glutathione-S-transferase (GST) activity can be used as candidate biomarkers of BDE-47exposure.