硝基芳烃化合物诱发细胞微核的比较研究

利用蚕豆根法细胞和人在淋巴细胞的微核试验对６种硝基芳烃化合物的致突变性进行比较研究，结果表明，邻二硝基苯、间二硝基苯、２，４－二硝基甲苯，２，６－二硝基甲苯，对硝基氯苯和对硝基溴苯均能诱发两咱细胞的微核率增加，除了对硝基溴苯外均具有明显剂量一效应关系。引进标准剂量概念比较５种硝基芳烃人合物的致突变性，结果表明，致突变性强弱依次为２，４－二硝基甲苯〉对硝基氯苯〉间二硝基苯〉２，６－二硝基甲苯〉邻二硝

Comparative Study on Micronucleus Induced by Nitro-aromatic Compounds in Different Cells

The mutagenicity of O-dinitrobenzene, M-dinitrobenzene, 2,6-dinitrotoluene, 2,4-dinitrotoluene, 4-chloronitrobenzene, 4-bromonitrobenzene were analysis by micronucleus test in vicia faba root tip cells and human peripheral blood lymphocytes. M-dinitrobenzene, 2,4-dinitrotoluene, 2,6-dinitrotoluene and O-dinitrobenzene all induced micronucleus formation in vicia faba root tip cells, and the dose-effect relationships were significant. In human peripheral blood lymphocytes all six nitro-aromatic compounds were positive, and dose-effect relationships were significant except 4-bromonitrobenzene. Compared with the defining dose, the mutagenicity of five nitro-aromatic compounds decreased in order of 2,4-dinitrotoluene, 4-chloronitrobenzene, M-dinitrobenzene, 2,6-dinitrotoluene, O-dinitrobenzene; the detected level of micronucleus test in vicia faba root tip cells was higher than that of micronucleus test in human peripheral blood lymphocytes.