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| 卤代酚对斑马鱼的急性联合毒性效应研究 | |
| 引用本文： | 杨永滨,刘征涛,郑明辉,杨 旭,方 征,王婉华.卤代酚对斑马鱼的急性联合毒性效应研究[J].环境科学研究,2007,20(2):5-8. |
| 作者姓名： | 杨永滨 刘征涛 郑明辉 杨 旭 方 征 王婉华 |
| 作者单位： | 1. 中国科学院,生态环境研究中心,环境化学与生态毒理国家重点实验室,北京,100085;河北大学,医学部,实验中心,河北,保定,071000 2. 中国环境科学研究院,国家环境保护化学品生态效应与风险评估重点实验室,北京,100012 3. 中国科学院,生态环境研究中心,环境化学与生态毒理国家重点实验室,北京,100085 4. 河北大学,医学部,实验中心,河北,保定,071000 |
| 摘 要： | 为了探讨卤代酚等毒性二元混合物联合毒性效应和评价其联合毒性效应的最佳方法,依次测定了6种卤代酚对斑马鱼的单一急性毒性和二元混合物的联合毒性,其中联合毒性作用类型采用毒性单位法(TU)、相加指数法(AI)和混合毒性指数法(MTI)分别进行评价.结果表明:单一卤代酚的生物毒性随着卤素原子数目在化合物中的增多呈增强趋势;卤代酚等毒性二元混合物的联合作用方式以部分相加和协同作用为主;毒性单位法(TU)和混合毒性指数法(MTI)可以较精确地评价卤代酚联合毒性作用类型. |
| 关 键 词： | 卤代酚 斑马鱼 联合毒性 |
| 文章编号： | 1001-6929（2007）02-0005-04 |
| 修稿时间： | 2006-09-18 |
Study on the Effects of Joint Acute Toxicities of Halophenols in Zebrafish |
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| YANG Yong-bin,LIU Zheng-tao,ZHENG Ming-hui,YANG Xu,FANG Zheng and WANG Wan-hua.Study on the Effects of Joint Acute Toxicities of Halophenols in Zebrafish[J].Research of Environmental Sciences,2007,20(2):5-8. | |
| Authors: | YANG Yong-bin LIU Zheng-tao ZHENG Ming-hui YANG Xu FANG Zheng and WANG Wan-hua |
| Institution: | 1. State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; 2. SEPA Key Laboratory of Ecological Effect and Risk Assessment of Chemicals, China Research Academy of Environmental Sciences, Beijing 100012, China; 3. Health Science Center, Hebei University, Baoding 071000, China |
| Abstract: | In order to study the joint toxicity effects of the equitoxic binary mixture of halophenols and the appropriate methods assessing their joint toxicity effects,the toxicities of single and binary mixtures of six halophenols to zebrafish were determined and the joint toxicity effects of the equitoxic binary mixture were assessed by the methods of toxic unit(TU),additional index(AI) and mixture toxic index(MTI)respectively.The results indicated that the single toxicity of the six halophenols enhanced with the increasing of the halogenoid atoms;that the joint effects of their binary equitoxic mixture were mainly partly additive and synergy;and that Toxic Unit and MTI could be regarded as the good methods to assess the joint toxicity effects of halophenols. |
| Keywords: | halophenols zebrafish joint toxicity |
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