| 五氯酚钠与二英对人外周血淋巴细胞的影响 |
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| 引用本文： | 方 征,刘征涛,李 响,王婉华,李 霁.五氯酚钠与二英对人外周血淋巴细胞的影响[J].环境科学研究,2006,19(2):20-22. |
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| 作者姓名： | 方 征 刘征涛 李 响 王婉华 李 霁 |
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| 作者单位： | 中国环境科学研究院,国家环境保护化学品生态效应与风险评估重点实验室,北京,100012 |
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| 摘 要： | 将五氯酚钠(Na-PCP)与二(噁)英(2,3,7,8-TCDD)作为受试物,观察了人外周血淋巴细胞的彗星率和微核率.结果显示:Na-PCP与二噁英各质量浓度组的彗星率与微核率均比阴性对照组有明显的增高(P＜0.001),而且随着质量浓度的增加而增高,呈明显的剂量-效应关系;阴性对照组与助溶剂对照组没有明显差异(P＞0.05);Na-PCP与二(噁)英(2,3,7,8-TCDD)会对人外周血淋巴细胞的DNA造成损伤,而且随着质量浓度的增加,其对DNA的损伤将更加严重;Na-PCP对人外周血淋巴细胞造成的损伤为联合毒性所致.
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| 关 键 词： | 五氯酚钠 二(噁)英 彗星试验 微核试验 淋巴细胞 |
| 文章编号： | 1001-6929（2006）02-0020-03 |
| 收稿时间： | 2005-05-19 |
| 修稿时间： | 2005-05-19 |
Infection of Lymphocyte from Human Peripheral Blood by Sodium Pentachlorophenate and Dioxins |
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| FANG Zheng,LIU Zheng-tao,LI Xiang,WANG Wan-hua and LI Ji.Infection of Lymphocyte from Human Peripheral Blood by Sodium Pentachlorophenate and Dioxins[J].Research of Environmental Sciences,2006,19(2):20-22. |
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| Authors: | FANG Zheng LIU Zheng-tao LI Xiang WANG Wan-hua and LI Ji |
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| Institution: | State Environmental Protection Key Laboratory for Ecological Effect and Risk Assessment of Chemicals, Chinese Research Academy of Environmental Sciences, Beijing 100012,China |
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| Abstract: | The comet assay and micronucleus assay were determined for lymphocyte from human peripheral blood,which is infected by Na-PCP and dioxins(2,3,7,8TCDD).Results indicated that comet rate and micronucleus rate of lymphocyte for the exposed groups were significantly higher than the control groups(P<0.001),and it has dose-effect relationship.The negative group is no different as compared with the flux groups(P>0.05).The Na-PCP and dioxins(2,3,7,8-TCDD) can damage DNA of lymphocyte from human peripheral blood,and the damage will rise with the increase of their mass concentrations.The damage from Na-PCP was caused by united toxicity. |
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| Keywords: | Na-PCP dioxins comet assay micronucleus assay lymphocyte |
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