| 太湖中微囊藻毒素的遗传毒性研究 |
| |
| 引用本文： | 宋瑞霞,刘征涛,沈萍萍.太湖中微囊藻毒素的遗传毒性研究[J].环境科学研究,2003,16(2):51-53. |
| |
| 作者姓名： | 宋瑞霞 刘征涛 沈萍萍 |
| |
| 作者单位： | 1.中国疾病预防与控制中心,环境与健康相关产品安全所,北京,100021 |
| |
| 基金项目： | 国家自然科学基金资助项目(29977020) |
| |
| 摘 要： | 应用Ames试验、小鼠骨髓嗜多染红细胞微核试验、小鼠精子畸形试验,对从太湖蓝藻水华中提取的微囊藻毒素进行测试.结果表明,太湖蓝藻水华中提取的微囊藻毒素对鼠伤寒沙门氏菌组氨酸缺陷型TA98菌株直接作用呈现致突变性,而经S9代谢活化作用后未呈现致突变性;可明显增强小鼠骨髓嗜多染红细胞的微核率,并呈现一定的剂量反应关系;但未引起小鼠精子畸变率的改变.
|
| 关 键 词： | 微囊藻毒素 Ames试验 小鼠骨髓嗜多染红细胞微核试验 小鼠精子畸形试验 |
| 文章编号： | 1001-6929(2003)02-0051-03 |
| 收稿时间： | 2002/8/15 0:00:00 |
Study on Genotoxicity of Microcystins Extracted from Waterbloom of Taihu Lake |
| |
| SONG Rui-xi,LIU Zheng-tao and SHEN Ping-ping.Study on Genotoxicity of Microcystins Extracted from Waterbloom of Taihu Lake[J].Research of Environmental Sciences,2003,16(2):51-53. |
| |
| Authors: | SONG Rui-xi LIU Zheng-tao and SHEN Ping-ping |
| |
| Institution: | 1.Institute for Environmental Hygiene and Health Related Products Safety,Center for Disease Control of China,Beijing 100021,China2.Chinese Research Academy of Environmental Sciences,Beijing 100012,China3.Department of Biochemistry,Nanjing University,Nanjing 210093,China |
| |
| Abstract: | Genotoxicity of microcystins extracted from waterbloom of Taihu Lake was detected using Ames test,micronucleus assay of mice bone marrow cell and mice sperm malformation test. The results showed that microcystins could induce the reverse mutagenesis of TA98 strain directly,but mutagenic effect disappeared after addition of S9,indicating no pro-mutagen in microcystins.Microcystins could significantly increase the mice bone marrow micronucleus frequency,and a dose-response relationship existed,but it did not increase mice sperm malformation rate. |
| |
| Keywords: | microcystins Ames test mice bone marrow micronucleus mice sperm malformation test |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《环境科学研究》浏览原始摘要信息 |
| 点击此处可从《环境科学研究》下载免费的PDF全文 |
