上呼吸道内可吸入颗粒物运动及沉降的模拟研究

建立了一个从人体口腔到前3级支气管的上呼吸道3维几何模型和流场计算模型以及可吸入颗粒物运动模型.将数值模拟结果与相关的实验数据进行了对比,表明数值模拟结果与实验结果基本吻合.在此基础上,在拉格朗日框架下追踪研究了可吸入颗粒物的运动轨迹,并统计了颗粒物在气道内不同部位的沉积分数;对人体上呼吸道内可吸入颗粒物的运动及沉积过程以及影响因素进行了分析.结果表明,可吸入颗粒物在上呼吸道内不同部位的沉积与呼吸强度、颗粒物密度以及粒径等因素密切相关;高呼吸强度时颗粒物在气管内的沉积分数明显升高,且随粒径的增大呈下降趋势;颗粒物在喉部的沉积分数最大,可以达到35%左右,但沉积分数受呼吸强度和粒径的影响相对较小;颗粒物在支气管内的沉积分数随粒径增大呈明显下降趋势;中小呼吸强度下颗粒物在支气管内的沉积分数明显高于高呼吸强度下的沉积分数.研究成果可以为可吸入颗粒物对人体健康影响的研究以及医学中气溶胶吸入疗法的研究等提供一定的依据.

Simulation Research on the Movement and Deposition of Inhalational Particles in the Human Respiratory Tract

An entire 3-dimensional geometry model from mouth, pharynx, larynx, trachea to triple bifurcation and the mathematics models for the calculation of the fluid flow and inhalational particle movement in the respiratory tract were proposed in this paper. The deposition fraction of inhalational particles in the respiratory tract obtained from the numerical simulation was coincident with the experimental data basically. Particles were traced in the Lagrangian frame, and at the same time, particle deposition fraction and position were recorded based on the models. The movement and deposition of the inhalational particles in the upper respiratory tract were analyzed. The results show that the deposition of inhalational particles in different positions have important correlation with the breathing intensity, particle density and particle diameter; deposition fraction of the inhalational particles in the trachea will increase at high breathing intensity and decrease with particle diameter increased; the deposition fraction of the inhalational particles in the larynx is maximal and can attain 35%, but the influence of the breathing intensity and particle diameter on the deposition fraction is smaller relatively; the deposition fraction of the inhalational particles in the triple bifurcation will decrease observably with particle diameter increased; the deposition fraction of the inhalational particles in the triple bifurcation is higher obviously at medium and small breathing intensity compared with that of high breathing intensity. The simulation results of this paper can provide a foundation for the research of the effect of inhalational particles on the human health and the research of the inhaling remedy in medicine.