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| 汞污染粮食诱导大鼠海马c-FOS蛋白表达 | |
| 引用本文： | 程金平,王文华,瞿丽雅,贾金平,郑敏.汞污染粮食诱导大鼠海马c-FOS蛋白表达[J].环境科学,2005,26(1):177-180. |
| 作者姓名： | 程金平 王文华 瞿丽雅 贾金平 郑敏 |
| 作者单位： | 1. 上海交通大学环境科学与工程学院,上海,200240 2. 贵州省环境保护科学研究所,贵阳,550002 3. 上海交通大学生命科学技术学院,上海,200240 |
| 基金项目： | 国家自然科学基金资助项目(20177013);上海交通大学985工程资助项目(113516001) |
| 摘 要： | 为了探讨我国典型汞污染地区汞污染生物效应 ,并尝试应用即刻早期基因c-fos表达变化早期预报典型汞污染地区汞神经毒性的可行性 ,本文应用免疫组织化学方法研究了实验粮食饲喂后 ,大鼠海马c-FOS蛋白表达变化 .结果表明污染粮食显著诱导大鼠海马c-FOS蛋白表达 ;在饲喂过程中硒与汞有拮抗效应 .初步推断 ,即刻早期基因c-fos表达变化可以作为汞污染地区汞神经毒性检测和评价效应指标 . |
| 关 键 词： | 汞污染粮食 c-fos 基因表达 海马 早期预报 |
| 文章编号： | 0250-3301(2005)01-0177-04 |
| 收稿时间： | 2004/3/17 0:00:00 |
| 修稿时间： | 2004/6/23 0:00:00 |
Expression of c-FOS Protein in Rat Hippocampus by Inducing of Mercury Contaminated Rice |
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| CHENG Jin-ping,WANG Wen-hu,QU Li-y,JIA Jin-ping and ZHENG Min.Expression of c-FOS Protein in Rat Hippocampus by Inducing of Mercury Contaminated Rice[J].Chinese Journal of Environmental Science,2005,26(1):177-180. | |
| Authors: | CHENG Jin-ping WANG Wen-hu QU Li-y JIA Jin-ping and ZHENG Min |
| Institution: | School of Environmental Science and Engineering, Shanghai Jiaotong University, Shanghai 200240, China. |
| Abstract: | In order to probe into the biological effects of mercury in typical mercury contaminated area and try to apply the expression of immediately early gene c-fos in brain to early predict the neurotoxicity of mercury in typical polluted areas, the expression of c-FOS protein in rat hippocampus is observed using immunocytochemical methods. The results show the mercury pollutes rice induced significantly the expression of c-FOS protein in hippccampus;the antagonisis between selenium and mercury on the exposure process. It is suggested that c-fos can be used as an effective index of detecting and assessing neurotoxicology of mercury polluted areas. |
| Keywords: | mercury contaminated rice c-fos gene expression hippocampus early prediction |
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