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Toxicological effects involved in risk assessment of rare earth lanthanum on roots of Vicia faba L. seedlings
作者姓名:Chengrun Wang  Mei He  Wen Shi  Jessie Wong  Tao Cheng  Xiaorong Wang  Lingling Hu  Fenfen Chen
作者单位:School of Life Science, Huainan Normal University, Huainan 232001, China;School of Life Science, Huainan Normal University, Huainan 232001, China;Department of Chemical and Biochemical Engineering, University of Western Ontario, London, ON, N6A5B9, Canada;Department of Biology, University of Western Ontario, London, ON, N6A5B9, Canada;School of Life Science, Huainan Normal University, Huainan 232001, China;State Key Laboratory of Pollution Control and Resources Reuse, School of the Environment, Nanjing University, Nanjing 210046, China;School of Life Science, Huainan Normal University, Huainan 232001, China;School of Life Science, Huainan Normal University, Huainan 232001, China
基金项目:This work was supported by the National Natural Science Foundation of China (No. 20877032) and the Foundation of State Key Laboratory of Pollution Control and Resources Reuse of China (No. PCRRF08011).
摘    要:Combined chemical analyses and biological measurements were utilized to investigate potential toxicological effects and possible mechanisms involved in risk assessment of rare earth elements (REEs) on Vicia faba L. seedlings, which were hydroponically cultivated and exposed to various concentrations of lanthanum (La) for 15 days. The results showed that La contents in both the solution and roots increased with the increase of extraneous La, contributing to hormetic dose responses of superoxide dismutase (SOD), catalase (CAT), guaiacol peroxidase (GPX), ascorbate peroxidase (APX) and endoprotease (EP) isozymes activities, and HSP 70 production enhanced at low doses but suppressed at higher doses of La. These physiological responses constituted antioxidant and detoxification systems against La-induced oxidative stress. The elevated La levels also contributed to oxidatively modified proteins, which were most responsible for subsequent cell death and growth retardation of the roots. By combination of hormetic and traditional threshold dose levels, the threshold dose range was deduced to be 108-195 μg La/g dry weight in the roots, corresponding to 0.90-3.12 mg/L of soluble La in the culture solution. It suggests that persistent applications of REEs may lead to potential ecological risk in the environment.

关 键 词:rare  earth  elements  lanthanum  heat  shock  protein  70  oxidatively  modified  proteins  isoenzymes  hormesis  risk  assessment
收稿时间:2010/11/27 0:00:00
修稿时间:2011/2/14 0:00:00

Toxicological effects involved in risk assessment of rare earth lanthanum on roots of Vicia faba L. seedlings
Chengrun Wang,Mei He,Wen Shi,Jessie Wong,Tao Cheng,Xiaorong Wang,Lingling Hu,Fenfen Chen.Toxicological effects involved in risk assessment of rare earth lanthanum on roots of Vicia faba L. seedlings[J].Journal of Environmental Sciences,2011,23(10):1721-1728.
Authors:Chengrun Wang  Mei He  Wen Shi  Jessie Wong  Tao Cheng  Xiaorong Wang  Lingling Hu and Fenfen Chen
Institution:1. School of Life Science, Huainan Normal University, Huainan 232001, China
2. Department of Chemical and Biochemical Engineering, University of Western Ontario, London, ON, N6A5B9, Canada
3. Department of Biology, University of Western Ontario, London, ON, N6A5B9, Canada
4. State Key Laboratory of Pollution Control and Resources Reuse, School of the Environment, Nanjing University, Nanjing 210046, China
Abstract:Combined chemical analyses and biological measurements were utilized to investigate potential toxicological effects and possible mechanisms involved in risk assessment of rare earth elements (REEs) on Vicia faba L.seedlings,which were hydroponically cultivated and exposed to various concentrations of lanthanum (La) for 15 days.The results showed that La contents in both the solution and roots increased with the increase of extraneous La,contributing to hormetic dose responses of superoxide dismutase (SOD),c...
Keywords:rare earth elements  lanthanum  heat shock protein 70  oxidatively modified proteins  isoenzymes  hormesis  risk assessment
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