| The crystal growth of hydroxyapatite in presence of collagens |
| |
| 作者姓名： | Zhang Fahao Wang Chunxi Wang Kui Xu Shanjin |
| |
| 作者单位： | Zhang Fahao，Wang Chunxia，Wang Kui and Xu ShanjinSchol of Pharmaceutical Sciences and Rescarch Laboratonies of Natural and Biomimetio drugs，Beijing Medical University，Beijing 100083，China. |
| |
| 摘 要： | The crystal growth of hydroxyapatite (HAP) seeds in presence of the abnormal collagen secreted by the chondrocyte grown in media containing free radical sources or fulvic acid and the type II collagen (pig cartilage) damaged by · OH and fulvic acid(FA) from potable water in endemic region of Kaschin-Beck disease (KBD) was studied. The results showed that in the former case, the abnormal collagen rich in type I collagen promoted mineralization in contrast with the type n collagen. The oxidatively damaged type II collagen became less inhibitive or even promotive. In all cases, the reaction followed a second order kinetics. The powder X-diffraction analysis and SEM observation indicated that the damaged type II collagen lowers the crystalinity in the beginning and made the final crystal more agglomerated. All the results showed that the abnormal and the damaged cartilage matrix affected the bimineralization and was likely to have played an important role in the development of KBD.
|
| 关 键 词： | collagen hydroxyapatite free redkal fulvic acid. |
| 收稿时间： | 1991/7/11 0:00:00 |
The crystal growth of hydroxyapatite in presence of collagens |
| |
| Zhang Fahao,Wang Chunxi,Wang Kui,Xu Shanjin.The crystal growth of hydroxyapatite in presence of collagens[J].Journal of Environmental Sciences,1991,3(4):60-66. |
| |
| Authors: | Zhang Fahao Wang Chunxia Wang Kui and Xu ShanjinSchol of Pharmaceutical Sciences and Rescarch Laboratonies of Natural and Biomimetio drugs Beijing Medical University Beijing China |
| |
| Institution: | Zhang Fahao,Wang Chunxia,Wang Kui and Xu ShanjinSchol of Pharmaceutical Sciences and Rescarch Laboratonies of Natural and Biomimetio drugs,Beijing Medical University,Beijing 100083,China. |
| |
| Abstract: | The crystal growth of hydroxyapatite (HAP) seeds in presence of the abnormal collagen secreted by the chondrocyte grown in media containing free radical sources or fulvic acid and the type II collagen (pig cartilage) damaged by · OH and fulvic acid(FA) from potable water in endemic region of Kaschin-Beck disease (KBD) was studied. The results showed that in the former case, the abnormal collagen rich in type I collagen promoted mineralization in contrast with the type n collagen. The oxidatively damaged type II collagen became less inhibitive or even promotive. In all cases, the reaction followed a second order kinetics. The powder X-diffraction analysis and SEM observation indicated that the damaged type II collagen lowers the crystalinity in the beginning and made the final crystal more agglomerated. All the results showed that the abnormal and the damaged cartilage matrix affected the bimineralization and was likely to have played an important role in the development of KBD. |
| |
| Keywords: | collagen hydroxyapatite free redkal fulvic acid |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《环境科学学报(英文版)》浏览原始摘要信息 |
| 点击此处可从《环境科学学报(英文版)》下载免费的PDF全文 |
