| Multi-biological defects caused by lead exposure exhibit transferable properties from exposed parents to their progeny in Caenorhabditis elegans |
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| 作者姓名： | WANG Da-yong YANG Peng |
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| 作者单位： | WANG Da-yong YANG Peng 1.Department of Genetics and Developmental Biology，Southeast University，Nanjing 210009，China. 2.Key Laboratory of Developmental Genes and Human Disease，Ministry of Education of China，Nanjing 210009，China |
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| 基金项目： | Project supported by the Southeast University Foundation for Excellent Young Scholars(No.4023001013) |
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| 摘 要： | Whether the multi-biological toxicity from lead exposure could be transferred to progeny has not been clarified.In the present study,we explored the Caenorhabditis elegans to analyze the multiple toxicities from lead exposure and their possibly transferable properties.The lead exposure could cause series of severe multi-biological defects with a concentration-dependent manner by affecting the endpoints of life span,development,reproduction and locomotion behaviors in nematodes.Moreover,most of these toxicities could be transferred to progeny from lead exposed animals and some of the defects in progeny appeared even more severe than in their parents,such as the body sizes and mean life spans.We summarized the defects caused by lead exposure into three groups according to their transferable properties or rescue patterns.That is,the defects caused by lead exposure could be largely,or partially,or became even more severe in progeny animals.Therefore,our results suggest that lead exposure can cause severely multi-biological defects,and most of these multiple toxicities can be considered as transferable for exposed animals in C.elegans.
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| 关 键 词： | 生物缺陷 毒性 可转移性 表型 |
| 收稿时间： | 25 January 2007 |
| 修稿时间： | 2007-01-25 |
Multi-biological defects caused by lead exposure exhibit transferable
properties from exposed parents to their progeny
in Caenorhabditis elegans |
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| WANG Da-yong,YANG Peng.Multi-biological defects caused by lead exposure exhibit transferable properties from exposed parents to their progeny in Caenorhabditis elegans[J].Journal of Environmental Sciences,2007,19(11):1367-1372. |
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| Authors: | WANG Da-yong and YANG Peng |
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| Institution: | Department of Genetics and Developmental Biology, Southeast University, Nanjing 210009, China;Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, Nanjing 210009, China |
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| Abstract: | Whether the multi-biological toxicity from lead exposure could be transferred to progeny has not been clarified. In the present study, we explored the Caenorhabditis elegans to analyze the multiple toxicities from lead exposure and their possibly transferable properties. The lead exposure could cause series of severe multi-biological defects with a concentration-dependent manner by affecting the endpoints of life span, development, reproduction and locomotion behaviors in nematodes. Moreover, most of these toxicities could be transferred to progeny from lead exposed animals and some of the defects in progeny appeared even more severe than in their parents, such as the body sizes and mean life spans. We summarized the defects caused by lead exposure into three groups according to their transferable properties or rescue patterns. That is, the defects caused by lead exposure could be largely, or partially, or became even more severe in progeny animals. Therefore, our results suggest that lead exposure can cause severely multi-biological defects, and most of these multiple toxicities can be considered as transferable for exposed animals in C. elegans. |
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| Keywords: | lead exposure toxicity transferable phenotype behavior C elegans Caenorhabditis elegans parents properties lead exposure results groups patterns body sizes mean life span animals reproduction locomotion nematodes development cause series severe defects |
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