首页 | 本学科首页   官方微博 | 高级检索  
     检索      


Enhanced hepatotoxicity induced by repeated exposure to polychlorinated biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin in combination in male rats
Authors:Yimei Wang  Chunfeng Lu  Zhiguo Sheng  Gang Liu  Ze Fu  Benzhan Zhu and Shuangqing Peng
Institution:1. Evaluation and Research Center for Toxicology,Institute of Disease Control and Prevention,Academy of Military Medical Sciences,Beijing 100071,China
2. Evaluation and Research Center for Toxicology,Institute of Disease Control and Prevention,Academy of Military Medical Sciences,Beijing 100071,China; Department of Pharmacology,Basic Medical College,Jiamusi University,Jiamusi 154007,China
3. State Key Laboratory of Environmental Chemistry and Ecotoxicology,Research Center for Eco-Environmental Sciences,Chinese Academy of Sciences,Beijing 100085,China
Abstract:2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and polychlorinated biphenyls (PCBs) are among persistent polyhalogenated aromatic hydrocarbons that exist as complex mixtures in the environment worldwide. The present study was attempted to investigate the hepatotoxicity following repeated exposure to TCDD and PCBs in combination in male rats, and to reveal the involvement of potential mechanisms. Male Sprague-Dawley rats were exposed to TCDD (10 g/kg) and Aroclor 1254 (10 mg/kg, a representative mixture of PCBs) alone or in combination by intragastric administration. After 12-day exposure, all treatments produced significant hepatotoxicity as characterized by changes of plasma biochemistry and histopathological changes. These e ects were more prominent in the combined group. Furthermore, all treatments induced hepatic cytochrome P450 1A1 (CYP1A1) expression, and the maximal level of CYP1A1 expression was observed in the combined group, as in the case of the most severe hepatotoxicity evoked by the combined exposure. These findings indicated that the hepatotoxicity induced by TCDD and Aroclor 1254 might be ascribed to the high expression of hepatic CYP1A1. The present study demonstrates the enhanced hepatotoxicity after exposure to TCDD and PCBs in combination in rats.
Keywords:2  3  7  8-tetrachlorodibenzo-p-dioxin  polychlorinated biphenyls  combined exposure  hepatotoxicity
本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录!
点击此处可从《环境科学学报(英文版)》浏览原始摘要信息
点击此处可从《环境科学学报(英文版)》下载免费的PDF全文
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号