Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center and UCLA School of Medicine, Los Angeles, CA, U.S.A.;2. Department of Pediatrics, University of Utah, Salt Lake City, UT, U.S.A.;3. Medical Genetics Birth Defects Center, Ahmanson Pediatric Center, SHARE'S Child Disability Center, Steven Spielberg Pediatric Research Center, Los Angeles, CA, U.S.A.;4. Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center and UCLA School of Medicine, Los Angeles, CA, U.S.A.;5. Meyers Institute, University of Nebraska, Omaha, NE, U.S.A.