| 辛基酚的体内类雌激素活性评价 |
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| 引用本文： | 朱毅,舒为群,等.辛基酚的体内类雌激素活性评价[J].重庆环境科学,2003,25(2):23-25. |
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| 作者姓名： | 朱毅 舒为群 |
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| 作者单位： | 第三军医大学预防医学系环境卫生学教研室 重庆400038
(朱毅，舒为群，田怀军，卓鉴波)，第三军医大学预防医学系环境卫生学教研室 重庆400038(李祥) |
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| 基金项目： | 国家自然科学基金资助 (项目编号 :3980 0 1 2 7) |
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| 摘 要： | 利用体内大鼠子宫增重试验检测辛基酚（OP）的类雌激素活性，并对其观测终点及影响因素进行了初步研究。结果显示，OP经大鼠体内染毒，可引起大鼠子宫湿重、子宫内皮细胞厚度、子宫腺数量明显增加，具有明显的类雌激素活性。三条染毒途径检测敏感度腹腔染毒＞经皮下染毒＞经灌胃染毒。
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| 关 键 词： | 类雌激素 活性评价 环境雌激素 辛基酚 子宫增重试验 活性检测 |
| 文章编号： | 1001-2141(2003)02-0023-03 |
| 修稿时间： | 2002年9月28日 |
Evaluation of Estrogenic Activity of Octylphenol in Vivo |
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| Zhu Yi,Shu Weiqun,Tian Huaijun,Zhuo Jianbo,Li Xiang.Evaluation of Estrogenic Activity of Octylphenol in Vivo[J].Chongqing Environmental Science,2003,25(2):23-25. |
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| Authors: | Zhu Yi Shu Weiqun Tian Huaijun Zhuo Jianbo Li Xiang |
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| Abstract: | To evaluate the estrogenic activity of octylphenol(OP) by uterus weight increase test in vivo.The results showed:The uterus weights of all the test groups were higher than the control group.The uterine endothelia cells of all the test group were thicker than the control group.The amount and volume of uterine glands increased significantly in the entire test group.The result suggested OP could stimulate the growth and maturing of uterus.By all the three administration way could induce the estrogenic activity,but their sensitivity were different,peritoneal injection > subderman injection > stomach gavage. |
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| Keywords: | Environmental estrogen(EE) Octylphenol(OP) Uterus weight increase test |
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