Enzymatic production of biosilica glass using enzymes from sponges: basic aspects and application in nanobiotechnology (material sciences and medicine) |
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| Authors: | Heinz C Schröder David Brandt Ute Schloßmacher Xiaohong Wang Muhammad Nawaz Tahir Wolfgang Tremel Sergey I Belikov Werner E G Müller |
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| Institution: | 1.Institut für Physiologische Chemie,Abteilung Angewandte Molekularbiologie, Universit?t,Mainz,Germany;2.National Research Center for Geoanalysis,Beijing,China;3.Institut für Anorganische Chemie und Analytische Chemie, Universit?t,Mainz,Germany;4.Limnological Institute of the Siberian Branch of Russian Academy of Sciences,Irkutsk,Russia |
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| Abstract: | Biomineralization, biosilicification in particular (i.e. the formation of biogenic silica, SiO2), has become an exciting source of inspiration for the development of novel bionic approaches following “nature as model”.
Siliceous sponges are unique among silica forming organisms in their ability to catalyze silica formation using a specific
enzyme termed silicatein. In this study, we review the present state of knowledge on silicatein-mediated “biosilica” formation
in marine sponges, the involvement of further molecules in silica metabolism and their potential application in nanobiotechnology
and medicine.
Werner E. G. Müller dedicated this study to Prof. Vera Gamulin (Rudjer Boskovic Institute, Zagreb, Croatia) in honour of her
unique contributions in molecular evolution. |
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| Keywords: | Biomineralization Biosilica Nanobiotechnology Silicatein Sponges Spicules |
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