Revisiting chronodisruption: when the physiological nexus between internal and external times splits in humans |
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Authors: | Thomas C Erren Russel J Reiter |
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Institution: | 1. Institute and Policlinic for Occupational Medicine, Environmental Medicine, and Prevention Research, University of Cologne, Lindenthal, Cologne, Germany 2. Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
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Abstract: | In this Concepts & Synthesis paper, we expand the definition of chronodisruption in humans by proposing that it can be operationalized as the split nexus of internal and external times. With this premise, we suggest how chronotype may be used as a temporal marker (chronomarker) of exposure to chronodisruption in studies of cancer, and beyond, offer cancer risk predictions for observational research on the basis of a chronotype-related hypothesis and corollary, and point to first empirical data in humans. In an a priori way, we examine possible outcomes and perspectives for preventive measures following from our rationale and the suggested chronobiology-driven studies and close with overall advances of chronodisruption research. |
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