Rückstände ausgewählter Humanarzneimittel in Oberflächenwasserkörpern im Einzugsgebiet Halle (Saale)

A method for the determination of 16 selected pharmaceuticals in surface water using LC-MS/MS has been developed Methods from literature were adapted within the scope of this study. The limit of quantification of 13 out of 16 analytes is below 10 ng/l. The analysis of samples from the Saale river and lakes around Halle demonstrated that Carbamacepin (Median 207 ng/l) and Diclofenac (Median 196 ng/l) are detectable at various sampling stations along the river. The wastewater path was identified as the most relevant source for pharmaceutical residues entering the environment. Besides, the results reveal increased levels of several substances in some smaller anabranches and brooks.