| 海洋微生物来源的天然产物开发研究进展 |
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| 引用本文： | 陈菲菲,王勇,王以光,赫卫清.海洋微生物来源的天然产物开发研究进展[J].应用与环境生物学报,2011(2):287-294. |
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| 作者姓名： | 陈菲菲 王勇 王以光 赫卫清 |
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| 作者单位： | 中国医学科学院/北京协和医学院医药生物技术研究所卫生部抗生素生物工程重点实验室;中国医药集团四川抗菌素工业研究所;中国科学院上海生命科学研究院植物生理生态研究所合成生物学重点实验室; |
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| 基金项目： | 中央级公益性科研院所基本科研业务费专项(No.IMBF20060202)资助~~ |
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| 摘 要： | 综述了近年来海洋微生物来源天然产物研究的新进展,总结了该类天然产物的开发策略.通过对样品采用不同的预处理方式、不同的分离培养基以及新的培养方法,讨论如何获得海洋来源的特有微生物和增加海洋来源微生物类群的多样性.阐述了在海洋微生物天然产物的开发过程中,采用宏基因组技术及基因组测序等手段,来发现难培养或不可培养微生物中的天然产物以及处于"沉默"状态的天然产物.最后介绍了异源生物合成、组合生物合成以及核糖体工程等技术在海洋微生物天然产物开发和改造中的应用,并举例论述了海洋微生物天然产物的开发.
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| 关 键 词： | 海洋微生物 宏基因组筛选 基因组测序 异源生物合成 组合生物合成 |
Advance in Research and Development of Natural Products from Marine Microorganisms |
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| CHEN Feifei,WANG Yong,WANG Yiguang & HE Weiqing.Advance in Research and Development of Natural Products from Marine Microorganisms[J].Chinese Journal of Applied and Environmental Biology,2011(2):287-294. |
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| Authors: | CHEN Feifei WANG Yong WANG Yiguang & HE Weiqing |
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| Institution: | CHEN Feifei1,2,WANG Yong2,3,WANG Yiguang1 & HE Weiqing1(1Key Laboratory of Biotechnology of Antibiotics,Ministry of Health,Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100050,China)(2Sichuan Industrial Institute of Antibiotics,Chengdu 610052,China)(3Key Laboratory of Synthetic Biology,Institute of Plant Physiology and Ecology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 200032,China) |
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| Abstract: | Giving a general summary of the strategies for exploring natural products from marine microorganisms,this article reviews the advances in research and development of natural products derived from marine microorganisms.Different sample pre-treated protocols,isolation media and new cultivation methods are introduced in this article in order to obtain marine-specific microorganisms as well as increase the diversity of marine microorganisms.Metagenomics screening and genome sequencing based mining as new strate... |
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| Keywords: | marine microorganisms metagenomics screening genome sequencing heterologous biosynthesis combinatorial biosynthesis |
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