Acute/chronic ratios to estimate chronic toxicity from acute data |
| |
| Authors: | Liping Wei Wenhua Zhang Shuokui Han Liansheng Wang Yuanhui Zhao |
| |
| Institution: | 1. State Key Laboratory of Pollution Control and Resource Reuse, Department of Environmental Science and Engineering , Nanjing University , Nanjing, 210093, P.R. China;2. Department of Environmental Science , North East Normal University , Jilin, 130022, P.R. China |
| |
| Abstract: | Acute toxicity of 25 narcotic compounds to D. magna was determined in this paper. Acute/ Chronic Ratios (ACRs), which are often used to estimate chronic toxicity from acute toxicity data, are discussed based on Quantitative Structure‐Activity Relationships (QSARs) of the compounds between both acute and chronic toxicity data and n‐octanol/water partition coefficients, and an improved equation is derived to estimate chronic toxicity data from acute toxicity data. Application of the improved equation and ACRs is illustrated for D. magna and fathead minnow to estimate chronic toxicity from acute toxicity. |
| |
| Keywords: | Acute toxicity data chronic toxicity data ACRs |
|
|
