Biochemical evaluation of hepatotoxicity in mice due to administration of artemether |
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| Authors: | AS Adekunle EO Agbedana BE Egbewale |
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| Institution: | 1. Faculty of Basic Medical Sciences, Department of Biochemistry , Ladoke Akintola University of Technology , Ogbomoso , Nigeria kunleniran@yahoo.com;3. Faculty of Basic Medical Sciences, Department of Chemical Pathology , University of Ibadan , Ibadan , Nigeria;4. Faculty of Basic Medical Sciences, Department of Biochemistry , Ladoke Akintola University of Technology , Ogbomoso , Nigeria;5. Faculty of Basic Medical Sciences, Department of Community Medicine , Ladoke Akintola University of Technology , Ogbomoso , Nigeria |
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| Abstract: | Effects of artemether administration on liver and selected biochemical parameters were evaluated. Eighty albino mice were divided into four equal groups. Group 1 was given water which served as control, while groups 2, 3, and 4 were given 1.2, 2.4, or 4.8 mg kg?1 body weight artemether intramuscularly for five consecutive days. On day 6 all mice were sacrificed by cervical dislocation and blood was collected for analysis of alanine and aspartate transaminases, alkaline phosphatase, copper, and total proteins. Liver tissues were prepared for histological studies. It was found that the serum alanine and aspartate transaminase and alkaline phosphatase activities were higher in groups treated with artemether compared to control. The serum concentrations of copper and total proteins were lower than control. The histological features of liver tissues after administration of artemether showed histopathological alterations. These findings showed that artemether administration may have reversible adverse effects on mouse hepatocytes. |
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| Keywords: | antimalaria artemether hepatotoxicity malaria mice biochemical parameters |
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