Synthesis of some novel (2-oxo-3-(arylimino) indolin-1-yl)-N-aryl acetamides and evaluation as antimicrobial agents |
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| Authors: | Biplab Debnath Swastika Ganguly |
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| Institution: | 1. Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Indiaphdph1001112@bitmesra.ac.in;3. Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, India |
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| Abstract: | A series of sixteen 2-oxo-3-(arylimino) indolin-1-yl)-N-aryl acetamide derivatives were synthesized, characterized by physical and spectral data (IR, 1H nuclear magnetic resonance (NMR), and mass spectrometry), and evaluated for their antibacterial and antifungal activities against various pathogenic microorganisms. Some of the synthesized compounds showed promising antibacterial and antifungal activities, the best being 2-(3-(4-chlorophenylimino)-2-oxoindolin-1-yl)-N-(3-methoxyphenyl) acetamide. |
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| Keywords: | isatin derivatives synthesis antimicrobial activity MIC |
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