Physiologically based pharmacokinetic modeling of perfluoroalkyl substances in the human body |
| |
| Authors: | Francesc Fàbrega Vikas Kumar Emilio Benfenati Marta Schuhmacher José L Domingo |
| |
| Institution: | 1. Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, Universitat Rovira i Virgili, Reus, Spain;2. Environmental Engineering Laboratory, Departament d'Enginyeria Química, Universitat Rovira i Virgili, Tarragona, Spain;3. Laboratory of Environmental Chemistry and Toxicity, Department of Environmental Health Sciences, IRCCS – Istituto di Ricerche Farmocologiche “Mario Negri”, Milano, Italy |
| |
| Abstract: | Currently, there are limited data on the levels of perfluoroalkyl substances other than perfluorooctane sulfonic acid and perfluorooctanoic acid in the human body. Most of this information has been extracted from biological monitoring of plasma while the occurrence of perfluoroalkyl substances in other human tissues is rarely studied. The objective of the present study was to develop a physiologically based pharmacokinetic model to assess the concentration of perfluoroalkyl substances in human tissues, based on an existing model previously validated for perfluorooctane sulfonic acid and perfluorooctanoic acid. Experimental data on concentrations of perfluoroalkyl substances in human tissues from individuals in Tarragona County (Catalonia, Spain) were used to estimate the values of some distribution and elimination parameters needed for the simulation. No significant correlations were found between these parameters and the chain lengths. The model was finally validated for five perfluoroalkyl substances. |
| |
| Keywords: | perfluoroalkyl substances PBPK modeling model validation human body elimination mechanisms |
|
|
