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Isolation of a new toxin from the sponge Latrunculia magnifica in the Gulf of Aquaba (Red Sea) |
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| Authors: | I Nèeman L Fishelson Y Kashman |
| Institution: | 1. Department of Biochemistry, Tel-Aviv University, The George S. Wise Center for Life Sciences, Tel-Aviv, Israel 2. Department of Zoology, Tel-Aviv University, The George S. Wise Center for Life Sciences, Tel-Aviv, Israel 3. Department of Organic Chemistry, Tel-Aviv University, Tel-Aviv, Israel |
| Abstract: | The sponge Latrunculia magnifica was found to be toxic for fish. A toxin has been isolated from this sponge by organic extraction-column chromatography and thin-layer chromatography. Several chemical properties of the toxin were determined by spectroscopic analysis. Toxicity tests were performed on the fish Gambusia affinis. In vitro experiments showed the toxin to be a cholinesterase inhibitor. |
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