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手性氟虫腈对意大利蜜蜂和稻螟赤眼蜂的急性毒性及安全评价
引用本文:苍涛,王新全,王彦华,吴长兴,吴声敢,陈丽萍,俞瑞鲜,赵学平.手性氟虫腈对意大利蜜蜂和稻螟赤眼蜂的急性毒性及安全评价[J].生态毒理学报,2012,7(3):326-330.
作者姓名:苍涛  王新全  王彦华  吴长兴  吴声敢  陈丽萍  俞瑞鲜  赵学平
作者单位:浙江省农业科学院农产品质量标准研究所 浙江省植物有害生物防控重点实验室&省部共建国家重点实验室培育基地农业部农药残留检测重点实验室,杭州,310021
基金项目:科技部国际合作项目(S2010GR0905);浙江省农业科学院博士启动基金项目
摘    要:手性农药多以外消旋体形式用于农业生产和卫生害虫防治中。但手性农药对映体通常具有不同的生物活性和毒性,这种现象在农药环境风险评价过程中往往被忽视。本研究以氟虫腈为例,首先用高效液相色谱-手性固定相(HPLC-CSP)技术拆分出氟虫腈的S型和R型2种对映体,分别采用点滴法和药膜法测定了氟虫腈对映体及外消旋体对意大利蜜蜂(Apis mellifera L.)和稻螟赤眼蜂(Trichogramma japonicum Ashmead)的急性毒性。结果显示,S(+)-氟虫腈、R(-)-氟虫腈和外消旋体对意大利蜜蜂的48h-LD50分别为0.00341、0.00396和0.00383μg·蜂-1,对稻螟赤眼蜂的24h-LR50分别为7.56×10-7、8.06×10-7和7.29×10-7mg·cm-2。研究表明,氟虫腈对意大利蜜蜂具有高毒性风险,对稻螟赤眼蜂有极高毒性风险,且氟虫腈对意大利蜜蜂和稻螟赤眼蜂的急性毒性无明显的对映体选择性。因此,使用氟虫腈单一对映体不会降低其对环境生物的毒害风险。

关 键 词:氟虫腈  蜜蜂  赤眼蜂  对映体选择性  急性毒性
收稿时间:2011/6/30 0:00:00
修稿时间:2011/7/27 0:00:00

Acute Toxicities and Safety Evaluation of Chiral Fipronil to Apis mellifera L. and Trichogramma japonicum Ashmead
Cang Tao,Wang Xinquan,Wang Yanhu,Wu Changxing,Wu Shenggan,Chen Liping,Yu Ruixian and Zhao Xueping.Acute Toxicities and Safety Evaluation of Chiral Fipronil to Apis mellifera L. and Trichogramma japonicum Ashmead[J].Asian Journal of Ecotoxicology,2012,7(3):326-330.
Authors:Cang Tao  Wang Xinquan  Wang Yanhu  Wu Changxing  Wu Shenggan  Chen Liping  Yu Ruixian and Zhao Xueping
Institution:State Key Laboratory Breeding Base for Zhejiang Sustainable Pest and Disease Control/Key Laboratory for Pesticide Residue Detection of Ministry of Agriculture, Institute of Quality Standards for Agricultural Products, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China;State Key Laboratory Breeding Base for Zhejiang Sustainable Pest and Disease Control/Key Laboratory for Pesticide Residue Detection of Ministry of Agriculture, Institute of Quality Standards for Agricultural Products, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China;State Key Laboratory Breeding Base for Zhejiang Sustainable Pest and Disease Control/Key Laboratory for Pesticide Residue Detection of Ministry of Agriculture, Institute of Quality Standards for Agricultural Products, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China;State Key Laboratory Breeding Base for Zhejiang Sustainable Pest and Disease Control/Key Laboratory for Pesticide Residue Detection of Ministry of Agriculture, Institute of Quality Standards for Agricultural Products, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China;State Key Laboratory Breeding Base for Zhejiang Sustainable Pest and Disease Control/Key Laboratory for Pesticide Residue Detection of Ministry of Agriculture, Institute of Quality Standards for Agricultural Products, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China;State Key Laboratory Breeding Base for Zhejiang Sustainable Pest and Disease Control/Key Laboratory for Pesticide Residue Detection of Ministry of Agriculture, Institute of Quality Standards for Agricultural Products, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China;State Key Laboratory Breeding Base for Zhejiang Sustainable Pest and Disease Control/Key Laboratory for Pesticide Residue Detection of Ministry of Agriculture, Institute of Quality Standards for Agricultural Products, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China;State Key Laboratory Breeding Base for Zhejiang Sustainable Pest and Disease Control/Key Laboratory for Pesticide Residue Detection of Ministry of Agriculture, Institute of Quality Standards for Agricultural Products, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China
Abstract:Most of the chiral pesticides were used as racemic forms in agricultural production and health pest control.However,differences existed in the biological activity and toxicity of the enantiomers of chiral pesticides,and the phenomena were usually ignored during the process of environmental risk evaluation of chiral pesticides.In this study,fipronil was selected as a model chiral pesticide,and its two enantiomers were isolated using an HPLC chiral stationary phase method(HPLC-CSP).The acute toxicities of S(+)-fipronil,R(-)-fipronil and racemic fipronil to Apis mellifera L.and Trichogramma japonicum Ashmead were investigated by the standard drop method and drug membrane method.Results showed that the 48 h-LD50 of S(+)-fipronil,R(-)-fipronil and racemic fipronil to A.mellifera were 0.00341,0.00396 and 0.00383 μg·bee-1,respectively.The 24 h-LR50 of S(+)-fipronil,R(-)-fipronil and racemic fipronil to T.japonicum were 7.56×10-7,8.06×10-7 and 7.29×10-7 mg·cm-2,respectively.It is demonstrated that fipronil was highly toxic to A.mellifera and very highly toxic to T.japonicum.No obvious differences in enantioselectivity were observed for acute toxicity of fipronil to A.mellifera and T.japonicum.Therefore,it is unlikely that the use of single enantiomer of fipronil would reduce the toxic risk to environmental organisms.
Keywords:fipronil  Apis mellifera  Trichogramma japonicum  enantioselectivity  acute toxicity
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