| 微囊藻毒素-LR致小鼠肝细胞DNA-蛋白质交联作用的研究 |
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| 引用本文： | 段丽菊,张慧珍,董玲,程学敏,崔留欣.微囊藻毒素-LR致小鼠肝细胞DNA-蛋白质交联作用的研究[J].生态毒理学报,2008,3(6). |
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| 作者姓名： | 段丽菊 张慧珍 董玲 程学敏 崔留欣 |
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| 作者单位： | 郑州大学公共卫生学院,郑州,450001 |
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| 基金项目： | Supported by Medicine Innovation Talent Projecting Stake Item in Henan Province (No. 200311205); the Japanese and Chinese CooperativeItem (No. 064SGHH36252-5) |
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| 摘 要： | 为探讨微囊藻毒素-LR致小鼠肝细胞的DNA-蛋白质交联作用,将20只昆明雄性小鼠随机分为4组:1个对照组和3个染毒组,采用腹腔注射进行染毒7d,染毒剂量分别为3.0、6.0和12.0μg·kg-1,检测小鼠肝细胞DNA-蛋白质交联程度.结果显示,3.0、6.0和12.0μg·kg-1微囊藻毒素-LR均可导致小鼠肝细胞显著的DNA-蛋白质交联作用(与对照组相比,p<0.01,p<0.01,p<0.05),当微囊藻毒素为6.0μg·kg-1时,这种作用最明显.
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| 关 键 词： | 微囊藻毒素-LR 雄性小鼠 交联作用 蛋白质 肝细胞 腹腔注射 交联程度 对照组 |
DNA-Protein Crosslinks Induced by Microcystin-LR in Hepatic Cells of Mice |
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| DUAN Li-ju,ZHANG Hui-zhen,DONG Ling,CHENG Xue-min,CUI Liu-xin.DNA-Protein Crosslinks Induced by Microcystin-LR in Hepatic Cells of Mice[J].Asian Journal of Ecotoxicology,2008,3(6). |
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| Authors: | DUAN Li-ju ZHANG Hui-zhen DONG Ling CHENG Xue-min CUI Liu-xin |
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| Abstract: | This study investigated the changes of DNA-protein crosslinks (DPC) in hepatic cells of mice that exposed to microcystin-LR (MCLR). Twenty male Kun Ming mice were divided into four groups: one control and three exposure groups. The control group were treated with saline and the exposure groups were treated with 3.0, 6.0 and 12.0μg·kg-1 MCLR respectively by injected intraperitoneally (i.p.) for 7d. Results showed that the DNA-protein crosslinks induced by MCLR exposures at 3.0, 6.0 and 12.0pμg·kg-1 were significant (p<0.01, p<0.01, p<0.05) compared with the control,and the 6.0μg·kg-1 exposure group was found to induce DNA-protein crosslinks most. In conclusion. MCLR can induce DNA-protein crosslinks in hepatic ceils of mice at the concentratioas of 3.0, 6.0 and 12.0μg·kg-1. |
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| Keywords: | microcytin-LR mouse hepatic cells DNA-protein crosslinks |
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