顺式和反式氯丹在家鸡体内的分布和转运

通过工业氯丹口服暴露实验,研究了顺式氯丹(CC)和反式氯丹(TC)在家鸡体内的吸收、代谢、排泄和在各个器官组织内富集的动态过程.分别测定了未暴露个体和一次性暴露后60、120、160、200、300、500、1000和2000min时脑、肝、肠、肌肉、皮、脂肪等组织和器官样品以及胃部和肠道残余物、排泄物中的氯丹含量.研究发现,暴露2000min后,95%以上的氯丹通过代谢途径被消除,只有少量氯丹通过排泄方式被消除;体内氯丹的消除满足一级反应动力学.研究还发现,在代谢过程中,反式氯丹快于顺式氯丹.另外,在吸收和代谢的过程中,有明显的手性特征,(+)-CC和(-)-TC更易被消除,但各个器官组织存在明显差异.

Distribution and Translocation of Trans- and Cis-Chlordane in Cock

The dynamic changes in absorption,metabolism,excretion and distribution among organs and tissues of trans-and cis-chlordane(TC and CC)in cocks were studied.After a single dose exposure of technical chlordane,concentrations of chlordane in brain,liver,intestine,muscle,skin,lipid,serum and residues in stomach and intestine as well as feces were measured at 60,120,160,200,300,500,1000 and 2000min against the control group without exposure.It was found that after 2000min,more than 95% of chlordane was metabolized with a small amount excreted.The depletion of chlordane in the body was a first-order process.The metabolization of TC was faster than CC.There were significant chiral signatures during the processes of absorption and metabolism,and(+)-CC and(-)-TC were easier to be depleted.Differences among various organs and tissues are observed.