二噁英类化合物的毒性作用机制及其生物检测方法

二噁英类化合物具有高毒性,来源多样且分布广泛,是持久性有机物的典型代表,二噁英类污染物及其对健康的危害已引起了公众的普遍关注。一些二噁英类同系物具有代谢稳定性,其毒性效应主要是通过芳香烃受体介导,而越来越多的研究表明二噁英类毒性作用机制的复杂性。在此背景下,综述了近些年在二噁英类毒性作用机制及其代谢途径的新认识,评价比较了主要二噁英类高通量生物检测方法,以期为该类污染物的环境污染物筛查和风险评估提供参考。

Review on the Toxic Mechanisms and Bioassay Approaches for Dioxin-like Compounds

The toxic dioxin-like compounds are typical representatives of persistent organic pollutants (POPs). They have a variety of sources and are attracted widespread attention. In past years, some congeners of dioxins and furans were thought metabolically stable in biota, and their toxic effects were mainly mediated through aryl hydrocarbon receptor (AhR). Recent research demonstrated that the toxic mechanisms of these AhR agonistic compounds should be more complicate then previously recognized. Based on recent research progress, this review article presents some new insights into the toxic modes of action (MoA) and metabolic pathways. Also, high-throughput bioassay approaches developed based on MoA were summarized for the sake of screening and risk assessment of dioxin-like compounds in environmental media.