首页 | 本学科首页   官方微博 | 高级检索  
     检索      

有机磷农药二元混合物联合效应评价新方法的研究
引用本文:朱涛,王本强,赵前进,王春花.有机磷农药二元混合物联合效应评价新方法的研究[J].生态毒理学报,2017,12(4):319-326.
作者姓名:朱涛  王本强  赵前进  王春花
作者单位:1. 安徽理工大学医学院,淮南,232001;2. 安徽理工大学数学与大数据学院,淮南,232001;3. 安徽理工大学医学院,淮南232001;莆田学院环境与生物工程学院,莆田351100
基金项目:安徽省高校自然科学研究项目(KJ2012Z380);国家自然科学基金项目(60973050)
摘    要:以敌敌畏、乐果联合作用于线虫的毒理学实验为基础,基于FH插值法理论,通过较少的实验数据建立有机磷农药二元混合物联合效应模型,求解作用效应表达式并绘制联合效应三维曲面图;基于合并用药分析公式,计算联合作用评价q值并绘制农药浓度与q值的联合作用评价三维曲面图,结果表明敌敌畏与乐果混合物联合作用不仅表现为相加作用,而且还在局部低浓度表现为拮抗作用,与多元统计分析结果一致。上述研究表明FH插值法理论可作为二元有机磷农药联合效应分析及评价的一种新方法。

关 键 词:有机磷农药  联合作用  联合效应  FH插值法  三维模型
收稿时间:2017/7/5 0:00:00
修稿时间:2017/8/23 0:00:00

Study on A New Method of Analyzing and Evaluating the Combined Effects of Binary Mixtures of Organophosphate Pesticides
Zhu Tao,Wang Benqiang,Zhao Qianjin,Wang Chunhu.Study on A New Method of Analyzing and Evaluating the Combined Effects of Binary Mixtures of Organophosphate Pesticides[J].Asian Journal of Ecotoxicology,2017,12(4):319-326.
Authors:Zhu Tao  Wang Benqiang  Zhao Qianjin  Wang Chunhu
Institution:1. College of Medicine, Anhui University of Science and Technology, Huainan 232001, China 2. College of Mathematics and Big Data, Anhui University of Science and Technology, Huainan 232001, China 3. College of Environmental and Biological Engineering, Putian University, Putian 351100, China
Abstract:Based on the results of the joint action of dichlorvos and dimathoate to Caenorhabditis elegans, the mathematical model about the combined effects of binary mixtures of organophosphate pesticides was established with fewer experimental data by the method of FH interpolation, so as to obtain the expression of combined effects and draw the three-dimension surface of the combined effects. According to the analysis formula of combined drugs, the q value of evaluating combined effects was calculated and the three-dimension surface of concentrations of pesticides and q value was drawn. The results showed the combined effect of the mixture of dichlorvos and dimethoate was additive, and locally antagonism showed in low concentrations range, which was in agreement with the results obtained by multivariate statistical analysis. It is demonstrated that FH interpolation could be used as a new method to evaluate combined effects of binary mixtures of organophosphate pesticides.
Keywords:organophosphate pesticides  joint action  combined effect  FH interpolation  three-dimension model
本文献已被 CNKI 万方数据 等数据库收录!
点击此处可从《生态毒理学报》浏览原始摘要信息
点击此处可从《生态毒理学报》下载免费的PDF全文
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号