| T-2毒素的毒性效应及致毒机制研究进展 |
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| 引用本文： | 邹广迅,张红霞,花日茂.T-2毒素的毒性效应及致毒机制研究进展[J].生态毒理学报,2011,6(2):121-128. |
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| 作者姓名： | 邹广迅 张红霞 花日茂 |
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| 作者单位： | 1. 安徽农业大学资源与环境学院，合肥 230031
2. 中国科学院动物研究所动物生态与保护生物学重点实验室，北京 100101;中国科学院动物研究所动物生态与保护生物学重点实验室，北京 100101;安徽农业大学资源与环境学院，合肥 230031 |
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| 基金项目： | 国家基金委青年基金项目(No. 201037004) |
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| 摘 要： | T-2毒素是由多种镰刀菌产生的单端孢霉烯族化合物中毒性较强的一种毒素,广泛存在于谷物和谷类食品中.经食物连续摄入T-2毒素会对人类和动物的健康造成潜在危害.目前,T-2毒素对人和动物健康的影响受到了社会的广泛关注,已成为毒理学领域研究的热点课题之一.在综述了T-2毒素的生物转化、代谢途径及其毒理学效应与机制基础上,对现...
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| 关 键 词： | T-2毒素 HT-2 生物转化 凋亡 毒理学效应 |
| 收稿时间： | 2010/10/29 0:00:00 |
| 修稿时间： | 2010/12/2 0:00:00 |
Research Progress in Toxicological Effects and Mechanism of T-2 Toxin |
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| Zou Guangxun,Zhang Hongxia and Hua Rimao.Research Progress in Toxicological Effects and Mechanism of T-2 Toxin[J].Asian Journal of Ecotoxicology,2011,6(2):121-128. |
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| Authors: | Zou Guangxun Zhang Hongxia and Hua Rimao |
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| Institution: | 1. School of Resources and Environment, Anhui Agricultural University, Hefei 230031, China
2. Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China;Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China;School of Resources and Environment, Anhui Agricultural University, Hefei 230031, China |
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| Abstract: | T-2 toxin belongs to a large group of trichothecene mycotoxins produced by various Fusarium molds. It is widely scattered in cereals and cereal, which can cause human and animal diseases. Concerning on its threat to the health of human and animals, T-2 toxin has been paid more attention. In this paper, recent advances in the toxicity of T-2 toxin are reviewed, including the biotransformation, metabolic pathways, the toxicological effects and the toxicological mechanisms of T-2 toxin. In addition, the present problems in the recent studies and the developing trend in research of T-2 toxin are discussed. |
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| Keywords: | T-2 toxin HT-2 biotransformation apoptosis toxicological effects |
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