| 秀丽线虫适应响应的形成与调控机理 |
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| 引用本文： | 范孟雪,王大勇.秀丽线虫适应响应的形成与调控机理[J].生态毒理学报,2011,6(6):571-576. |
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| 作者姓名： | 范孟雪 王大勇 |
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| 作者单位： | 东南大学医学院生物化学与分子生物学系,南京,210009 |
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| 基金项目： | 国家重点基础研究发展计划(No. 2011CB933404)；国家自然科学基金（No. 81172698） |
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| 摘 要： | 除了环境暴露评价,在环境毒理学研究中模式动物秀丽线虫也已经被应用于适应响应形成及其调控机理研究.在综述中,系统介绍了秀丽线虫中存在的几种形式毒物诱发的适应响应,即同一因素适应响应、交叉适应响应与特殊形式的适应响应；讨论了目前已经揭示出的6种影响适应响应形成因素；分析了适应响应形成可能机制,即抗氧化应激体系、热激蛋白、金...
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| 关 键 词： | 适应响应 调控因子 调控机理 秀丽线虫 |
| 收稿时间： | 5/2/2011 12:00:00 AM |
| 修稿时间： | 2011/7/27 0:00:00 |
Formation and Regulation Mechanism of Adaptive Response in Nematode Caenorhabditis elegans |
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| Fan Mengxue and Wang Dayong.Formation and Regulation Mechanism of Adaptive Response in Nematode Caenorhabditis elegans[J].Asian Journal of Ecotoxicology,2011,6(6):571-576. |
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| Authors: | Fan Mengxue and Wang Dayong |
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| Institution: | Department of Biochemistry and Molecular Biology, Medical School of Southeast University, Nanjing 210009, China;Department of Biochemistry and Molecular Biology, Medical School of Southeast University, Nanjing 210009, China |
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| Abstract: | Besides environmental exposure evaluation,model animal of Caenorhabditis elegans has also been used in the studies of formation and regulation mechanism of adaptive response in environmental toxicology.In this review,three types of adaptive response existed in C.elegans were introduced,which are hormesis,cross-adaptation,and dietary restriction.Six known factors influencing the formation of adaptive response were analyzed.The possible mechanisms explaining adaptive response formation were discussed.Especial... |
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| Keywords: | adaptive response regulating factor regulation mechanism Caenorhabditis elegans |
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