脂质组学在环境领域中的应用

脂质是生物体内重要的组成物质之一,具有多种重要的生物学功能。脂质组学作为代谢组学的一个重要分支,主要通过研究生物体内脂质化合物及脂质代谢谱的变化,进而鉴定生物标志物,分析相关代谢通路,阐明生物体响应外界刺激的机制。随着分析技术的不断进步,尤其是色谱和质谱技术的引入,极大地推动了脂质组学研究的发展,并扩展了其应用范围。本文介绍了脂质组学的研究方法及其在环境领域中的应用前景,重点讨论了脂质组学及多组学联用技术在环境胁迫耐受性及环境污染物毒性评价中的应用。

Application of Lipidomics in Environmental Research

Lipid is one of the important biological components, and it plays multiple critical roles in cellular functions. As a branch of metabolomics, lipidomics is aimed at specific analysis of the alteration of lipid metabolism, identification of lipid biomarkers, and understanding the pathways that respond to physiological perturbation. The advance of modern analytical technology, especially with the use of mass spectrometry and chromatography in the research, has significantly accelerated the development of lipidomics and broadened its application in recent years. Here we introduce the methodology of lipidomics and its application in environmental research fields. We mainly discussed the application of lipidomics and multiple omics technologies in the response of organisms to environmental stress and in the toxicological evaluation of environmental contaminants.