我国大气环境毒理学研究新进展

对大气环境中重要污染物的毒理学作用及其机制方面的文献进行综述。首先,总结了细颗粒物(PM2.5)和纳米颗粒物对呼吸系统和心血管系统毒理学作用及其机理方面的研究;然后,评述了二氧化硫(SO2)对基因表达的影响及内源性SO2生理作用方面的研究,提出SO2既是一种全身性毒物,又是一种新型信号分子的新观点;对大气环境致癌物,特别是有关苯并芘致癌作用分子机制的研究进行讨论;对大气中臭氧和光化学烟雾对健康影响的研究作了评述;最后,对室内空气污染物尤其是甲醛的毒性作用及其机理方面的最新研究进行了评论。

Current Progress in Atmospheric Environmental Toxicology in China

Toxicological effects and mechanisms of important pollutants in the atmospheric environment are reviewed.Firstly,the studies on toxicological effects and mechanisms of fine particles (PM2.5) and nanometer particles on respiratory and cardiovascular systems are summarized.Secondly,the investigations on effects of sulfur dioxide (SO2) on gene expressions and physiological roles of endogenous SO2 are commented.It is proposed that SO2 is a systemic toxin and a new type-gas transmitter.Thirdly,the molecular carcinogenesis mechanisms of carcinogens in the atmospheric environment,especially benzopyrene,are discussed.Fourthly,toxic effects of atmospheric ozone and photochemical smog on health are summerized.Finally,the up to date studies on toxic effects and mechanisms of indoor air pollutants,especially formaldehyde,are commented.