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镉造成心血管损害毒性机制的研究进展
引用本文:詹杰,周启星,魏树和.镉造成心血管损害毒性机制的研究进展[J].生态毒理学报,2011,6(5):466-470.
作者姓名:詹杰  周启星  魏树和
作者单位:1. 辽宁省基础医学研究所,沈阳 110101 2. 中国科学院沈阳应用生态研究所陆地生态过程重点实验室,沈阳 110016;中国科学院沈阳应用生态研究所陆地生态过程重点实验室,沈阳 110016;中国科学院沈阳应用生态研究所陆地生态过程重点实验室,沈阳 110016
基金项目:国家自然科学基金(31070455;40971184;40930739);国家“863”计划(2009AA06Z316);中国博士后基金(20090461195;20103626)
摘    要:镉是一种极易在人体内蓄积的有毒元素,长期的生物蓄积和生物放大,会对机体产生一系列的损伤,其中,对心血管系统的损伤包括易造成动脉硬化、高血压和心肌病等.本文将镉在心血管损伤方面的毒作用的研究进展进行了总结,包括镉对心血管的氧化损伤,对心血管粘附因子的破坏,对心血管内皮细胞的功能和DNA损伤修复机制的破坏,以及对心血管内皮...

关 键 词:  心血管损害  毒理机制
收稿时间:2010/10/15 0:00:00
修稿时间:7/4/2011 12:00:00 AM

Research Advances in Mechanism for Cardiovascular Toxicity of Cadmium
Zhan Jie,Zhou Qixing and Wei Shuhe.Research Advances in Mechanism for Cardiovascular Toxicity of Cadmium[J].Asian Journal of Ecotoxicology,2011,6(5):466-470.
Authors:Zhan Jie  Zhou Qixing and Wei Shuhe
Institution:1. Institute of Basic Medicine of Liaoning Province, Shenyang 110101, China 2. Key Laboratory of Terrestrial Ecological Process, Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China;Key Laboratory of Terrestrial Ecological Process, Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China;Key Laboratory of Terrestrial Ecological Process, Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China
Abstract:Cadmium (Cd) is a cumulative heavy metal poison which may exert a wide variety of adverse effects on humans through bioconcentration and biomagnification processes. The cardiovascular injuries caused by Cd include atherosclerosis, hypertension and cadiomyopathy. This review aims to summarize the toxicological mechanism of Cd on cardiovascular system, including oxidative damage, adhesion molecules damage, damage to functions of vascular endothelial cells, damage to DNA repairing system, and promotion of apoptosis of vascular endothelial cells. Conducting a systematic research on the toxicological mechanism of Cd-induced cardiovascular disease is suggested as one of the focuses of the future study in this area.
Keywords:cadmium  cardiovascular damage  toxicological mechanism
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