代谢组学方法在生态毒理学中的应用进展

代谢组学方法越来越多地用于研究有机体与生态环境的相互作用。近年来,该方法已被应用于化学物风险评价和野生动物的疾病诊断,成为环境科学,特别是生态毒理学中充满活力的研究方向之一。本文介绍了应用于代谢组学研究的核磁共振波谱和质谱2种检测技术,着重讨论了生态毒理学研究中代谢组学方法在生物标志物的发掘和毒性评价,以及有机体对环境影响因子的代谢响应、野生水生动物疾病的诊断和监测等方面的应用。这些代谢组学在生态毒理学领域的应用将促进对有机体与环境相互作用的认识。

Progress in Application of Metabonomic Approaches in Ecotoxicology

Metabonomics methodology is increasingly being applied to investigate the interactions of organisms with their natural ecological environment. Recently, this method has been applied to chemical risk assessment and diagnosis of diseases in wild animals, becoming one of the vibrant research areas in environmental science and ecological toxicology in particular. This article introduced two detecting and measuring technologies, i.e., nuclear magnetic resonance spectroscopy and mass spectrometry, which are commonly used in metabonomics. This review focused on the application of metabonomics approach in biomarker development and risk assessment of toxicants exposure, metabonomic responses to environmental stressors, and disease diagnosis and monitoring of wild aquatic animals. This growing application of metabolomics in ecotoxicology is believed to shed new light on understanding of important questions related to organism-environment interactions.